Results 71 to 80 of about 430,778 (289)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Cubic trigonometric B-spline differential quadrature method for numerical treatment of Fisher’s reaction-diffusion equations

Alexandria Engineering Journal, 2018
This paper concerns through the numerical treatment of Fisher’s reaction-diffusion equation by using a hybrid numerical method. In this method, the combination of cubic trigonometric B-spline (CTB) base functions and differential quadrature method is ...
Mohammad Tamsir, Neeraj Dhiman, Vineet K. Srivastava   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

An Optimally Stable and Accurate Second‐Order SSP Runge‐Kutta IMEX Scheme for Atmospheric Applications

Journal of Advances in Modeling Earth Systems, 2018
The objective of this paper is to develop an optimized implicit‐explicit (IMEX) Runge‐Kutta scheme for atmospheric applications focusing on stability and accuracy.
Arman Rokhzadi, Abdolmajid Mohammadian, Martin Charron   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Silica-Nanocoated Membranes with Enhanced Stability and Antifouling Performance for Oil-Water Emulsion Separation

Membranes
Despite the potential of glass fiber (GF) membranes for oil-water emulsion separations, efficient surface modification methods to enhance fouling resistance while preserving membrane performance and stability remain lacking.
Mengfan Zhu, Chengqian Huang, Yu Mao
doaj   +1 more source

Thetis coastal ocean model: discontinuous Galerkin discretization for the three-dimensional hydrostatic equations [PDF]

Geoscientific Model Development, 2018
Unstructured grid ocean models are advantageous for simulating the coastal ocean and river–estuary–plume systems. However, unstructured grid models tend to be diffusive and/or computationally expensive, which limits their applicability to real-life ...
T. Kärnä, T. Kärnä, S. C. Kramer, L. Mitchell, L. Mitchell, L. Mitchell, D. A. Ham, M. D. Piggott, A. M. Baptista   +8 more
doaj   +1 more source

On the Total Variation of High-Order Semi-Discrete Central Schemes for Conservation Laws [PDF]

, 2004
We discuss a new fifth-order, semi-discrete, central-upwind scheme for solving one-dimensional systems of conservation laws. This scheme combines a fifth-order WENO reconstruction, a semi-discrete central-upwind numerical flux, and a strong stability ...
Bryson, Steve, Levy, Doron
core   +1 more source

Entropy stable DGSEM for nonlinear hyperbolic systems in nonconservative form with application to two-phase flows

, 2018
In this work, we consider the discretization of nonlinear hyperbolic systems in nonconservative form with the high-order discontinuous Galerkin spectral element method (DGSEM) based on collocation of quadrature and interpolation points (Kopriva and ...
Renac, Florent
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source