Results 81 to 90 of about 491,070 (354)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

On Strongly Regular Graphs and the Friendship Theorem

Mathematics
This paper presents an alternative proof of the celebrated friendship theorem, originally established by Erdős, Rényi, and Sós in 1966. The proof relies on a closed-form expression for the Lovász ϑ-function of strongly regular graphs, recently derived by
Igal Sason
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

On the locating matrix of a graph and its spectral analysis [PDF]

Computer Science Journal of Moldova, 2017
We introduce a new matrix representation for a graph by defining the locating matrix $\mathbf{Lo}(G)$ of $G$. We define the locating eigenvalues, the locating spectrum, and locating energy of the graph and we calculate them for some standard graphs.
H. N. Ramaswamy, Anwar Alwardi, N. Ravi Kumar   +2 more
doaj  

Critical groups of van Lint-Schrijver Cyclotomic Strongly Regular Graphs

, 2019
The \emph{critical} group of a finite connected graph is an abelian group defined by the Smith normal form of its Laplacian. Let $q$ be a power of a prime and $H$ be a multiplicative subgroup of $K=\mathbb{F}_{q}$.
Pantangi, Venkata Raghu Tej
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

θ-regular spaces

International Journal of Mathematics and Mathematical Sciences, 1985
In this paper we define a topological space X to be θ-regular if every filterbase in X with a nonempty θ-adherence has a nonempty adherence. It is shown that the class of θ-regular topological spaces includes rim-compact topological spaces and that θ ...
Dragan S. Janković
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

New bounds for the max-$k$-cut and chromatic number of a graph

, 2015
We consider several semidefinite programming relaxations for the max-$k$-cut problem, with increasing complexity. The optimal solution of the weakest presented semidefinite programming relaxation has a closed form expression that includes the largest ...
Sotirov, Renata, van Dam, Edwin R.
core   +2 more sources