Results 91 to 100 of about 105,061,129 (288)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Contributions of Physical Activity and Positive Psychological Functioning to Flow and Well-Being
SportsStudies highlight the importance of physical activity (PA) in relation to positive psychological functioning (PPF) among adults. Physical inactivity is strongly associated with lower levels of PPF, supporting the idea that lifestyle choices can be ...
Nuno Rodrigues +4 more
doaj +1 more source
, 2001 Strongly regular grahphs and directed strongly regular graphs are introduced. Examples of strongly regular graphs are give: Conference graph and latin square graphs. The existence of a directed strongly regular graph with t=0.
Thomsen, Jakob Peter
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Soil sodicity originating from marginal groundwater
Vadose Zone Journal, 2020 Soil salinity and sodicity are among the oldest soil and groundwater pollution problems and are widespread across the globe. Where salinity affects crop water uptake and yield, sodicity may additionally cause poorly reversible soil structure degradation ...
Daniël vande Craats +5 more
doaj +1 more source
, 2018 29 pages. To appear in the Proceedings of the Workshop "Pseudorandomness and Finite Fields" at RICAM, Linz, Austria, Oct.
Momihara, Koji, Wang, Qi, Xiang, Qing
openaire +2 more sources
Hamiltonian Strongly Regular Graphs [PDF]
, 2008 We give a sufficient condition for a distance-regular graph to be Hamiltonian. In particular, the Petersen graph is the only connected non-Hamiltonian strongly regular graph on fewer than 99 ...
Andries E. Brouwer +4 more
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source