Results 61 to 70 of about 111,506 (251)

On(strongly) regular relations on soft topological hypergroups

Filomat
In the first step, we determine some conditions for having a topological complete hypergroup by defining the geometric space obtained from each strongly regular relation. Then applying set theory, we introduce the concepts of ?soft geometric spaces,? ?soft topological hypergroups,? and ?(strongly) regular relations? on soft hypergroups.
Asieh Pourhaghani, Hamid Torabi
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice

Cells, 2019
Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD ...
Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Marta Zarà, Nico Mitro, Francis S. Lee, Elena Tremoli, Silvia Stella Barbieri   +7 more
doaj   +1 more source

Selenium deficiency is linearly associated with hypoglycemia in healthy adults

Redox Biology, 2020
Objective: The trace element selenium (Se) is needed for regular biosynthesis of selenoproteins, which contribute to antioxidative defense systems and affect redox-regulated signaling.
Yue Wang, Eddy Rijntjes, Qian Wu, Hongjun Lv, Chuqi Gao, Bingyin Shi, Lutz Schomburg   +6 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Equivalent Standard Forms of a Class of Tropical Matrices and Centralizer Groups

Mathematics
In this paper, the equivalent standard forms of tropical idempotent strongly definite matrices are introduced. In particular, the observation of the equivalent standard forms of tropical idempotent normal matrices is given.
Yanliang Cheng
doaj   +1 more source

Viscosity Methods of Asymptotically Pseudocontractive and Asymptotically Nonexpansive Mappings for Variational Inequalities

Abstract and Applied Analysis, 2012
Let {𝑡𝑛}⊂(0,1) be such that 𝑡𝑛→1 as 𝑛→∞, let 𝛼 and 𝛽 be two positive numbers such that 𝛼+𝛽=1, and let 𝑓 be a contraction. If 𝑇 be a continuous asymptotically pseudocontractive self-mapping of a nonempty bounded closed convex subset 𝐾 of a real reflexive ...
Xionghua Wu, Yeong-Cheng Liou, Zhitao Wu, Pei-Xia Yang   +3 more
doaj   +1 more source

Serum visfatin in chronic renal failure patients on maintenance hemodialysis: A correlation study

The Egyptian Journal of Internal Medicine, 2013
Background and aim of work Endothelial dysfunction, atherosclerosis, and cardiovascular disease are strongly linked to chronic kidney disease. It has been hypothesized that visfatin may play an important role in uremia-related atherosclerosis and the ...
Abdel Wahab M Lotfy, Nagwa A Mohammed, Hanan M El-Tokhy, Fatma A Attia   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source