Results 81 to 90 of about 1,088,616 (274)

Avalanche activity and socio-environmental changes leave strong footprints in forested landscapes: a case study in the Vosges medium-high mountain range

open access: yesAnnals of Glaciology, 2018
The medium-high mountain ranges of Western Europe are undergoing rapid socio-environmental changes. The aim of this study is to show that their landscape can be strongly shaped by the actions of avalanche activity, humans and climate.
Florie Giacona   +8 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Knowledge About and Attitudes towards End of Life Care for Gay, Lesbian, Bisexual & Transgender People (Phase 2) [PDF]

open access: yes, 2010
Increasing evidence suggests that many gay, lesbian, bisexual and transgender (GLBT) people are being denied their legal rights in their own end-of-life care and the end-of-life care of their partners and other important people in their lives. A study in
Colleen Cartwright   +2 more
core  

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice

open access: yesCells, 2019
Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD ...
Leonardo Sandrini   +7 more
doaj   +1 more source

Selenium deficiency is linearly associated with hypoglycemia in healthy adults

open access: yesRedox Biology, 2020
Objective: The trace element selenium (Se) is needed for regular biosynthesis of selenoproteins, which contribute to antioxidative defense systems and affect redox-regulated signaling.
Yue Wang   +6 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

The Equivalent Standard Forms of a Class of Tropical Matrices and Centralizer Groups

open access: yesMathematics
In this paper, the equivalent standard forms of tropical idempotent strongly definite matrices are introduced. In particular, the observation of the equivalent standard forms of tropical idempotent normal matrices is given.
Yanliang Cheng
doaj   +1 more source

Viscosity Methods of Asymptotically Pseudocontractive and Asymptotically Nonexpansive Mappings for Variational Inequalities

open access: yesAbstract and Applied Analysis, 2012
Let {𝑡𝑛}⊂(0,1) be such that 𝑡𝑛→1 as 𝑛→∞, let 𝛼 and 𝛽 be two positive numbers such that 𝛼+𝛽=1, and let 𝑓 be a contraction. If 𝑇 be a continuous asymptotically pseudocontractive self-mapping of a nonempty bounded closed convex subset 𝐾 of a real reflexive ...
Xionghua Wu   +3 more
doaj   +1 more source

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