Results 51 to 60 of about 7,745 (264)
Development and Psychometric Analysis of the Student-Teacher Relationship Scale - Short Form
Frontiers in Psychology, 2015 The purpose of this study is the construction and validation of an Italian Short Form version of the Student-Teacher Relationship Scale (Pianta 2001; STRS-SF) in the Italian educational setting for 1256 Students and 210 teachers.
Michele eSettanni +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Annals of Human Biology, 2018 Background: Tandem repeats (STRs) are genomic markers of particular interest in forensic and population genetics. Most of the population data currently available correspond to the variation of STRs of forensic panels, which barely include dinucleotide ...
Josep Santamaría +4 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Assessment of the forensic application of 50 Y-STR markers in a large pedigree
Forensic Sciences Research, 2020 Short tandem repeats on the Y chromosome (Y-STRs), characterized by paternal inheritance, are valuable in forensic practice. Notably, the potential application of Y-STRs in pedigrees should be drawn upon, especially in China’s surname-concentrated ...
Yi Ye +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Application of X-STRs for Forensic Identification in Mixed DNA Profile: A Case Report
Forensic SciencesAutosomal polymorphisms (STRs) or Y-Chromosome polymorphisms (Y-STRs) are usually used for the study and deconvolution of mixed DNA profiles in forensic genetics, accompanying data interpretation with biostatistical evaluations (e.g., RMP, RMNE, LR ...
Nunzia Ilaria Vacca +4 more
doaj +1 more source
A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave.
PLoS ONE, 2014 Structural genetic variants as short tandem repeats (STRs) are not targeted in SNP-based association studies and thus, their possible association signals are missed.
Claudia Lamina +11 more
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Genome-wide detection of short tandem repeat expansions by long-read sequencing
BMC Bioinformatics, 2020 Background Short tandem repeat (STR), or “microsatellite”, is a tract of DNA in which a specific motif (typically
Qian Liu, Yao Tong, Kai Wang
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source