Results 211 to 220 of about 69,991 (228)
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Development of Mechanism-Based Structural Alerts for Respiratory Sensitization Hazard Identification
Chemical Research in Toxicology, 2012This study outlines how mechanistic organic chemistry related to covalent bond formation can be used to rationalize the ability of low molecular weight chemicals to cause respiratory sensitization. The results of an analysis of 104 chemicals which have been reported to cause respiratory sensitization in humans showed that most of the sensitizing ...
Enoch, S. J. +5 more
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Genotoxic Impurities: From Structural Alerts to Qualification
Organic Process Research & Development, 2010The presence of an in cerebro structural alert in a potential or actual impurity, most likely arising as a byproduct or carried-over reagent or starting material, in a drug substance or drug product is merely an indication that the compound may be a DNA-reactive genotoxin.
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Atmospheric Environment, 2002
The seasonal snowpackat Alert (North coast of Ellesmere Island, 82 129.94 0 N, 62120.55 0 W) was studied in February and April 2000, on land and on sea ice. The stratigraphy was studied, and the density and specific surface area (SSA) of each snow layer were measured. SSA was measured by CH4 adsorption at 77 K using a volumetric method.
Florent Dominé +2 more
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The seasonal snowpackat Alert (North coast of Ellesmere Island, 82 129.94 0 N, 62120.55 0 W) was studied in February and April 2000, on land and on sea ice. The stratigraphy was studied, and the density and specific surface area (SSA) of each snow layer were measured. SSA was measured by CH4 adsorption at 77 K using a volumetric method.
Florent Dominé +2 more
openaire +1 more source
International Journal of Toxicology, 2011
In the process of drug design, it is important to consider potential structural alerts that may lead to toxicosis. This work illustrates how using trifluoroethane as a part of a novel chemical entity led to cytochrome P450 – mediated N-dealkylation and the formation of trifluoroacetaldehyde, a known testicular toxicant, in exploratory safety studies in
Martin E, Dowty +4 more
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In the process of drug design, it is important to consider potential structural alerts that may lead to toxicosis. This work illustrates how using trifluoroethane as a part of a novel chemical entity led to cytochrome P450 – mediated N-dealkylation and the formation of trifluoroacetaldehyde, a known testicular toxicant, in exploratory safety studies in
Martin E, Dowty +4 more
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Identifying Structural Alerts Based on Zebrafish Morphological Toxicity
2017Presented at ...
Jui-Hua Hsieh +4 more
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Emerging Patterns as Structural Alerts for Computational Toxicology
2012Thanks to significant advances on both the algorithmic and the practical sides, mining graph data has turned into a key domain of data mining. Various domains use graphs to model their data and graph patterns have widely demonstrated their potential, especially in the field of chemoinformatics where chemical structures are commonly modeled as graphs ...
Cuissart, Bertrand +4 more
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Paper alert: Structural biology
Current Opinion in Structural Biology, 2001Máire Convery +18 more
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