Results 51 to 60 of about 69,991 (228)

JEERP: Energy Aware Enterprise Resource Planning [PDF]

, 2014
Ever increasing energy costs, and saving requirements, especially in enterprise contexts, are pushing the limits of Enterprise Resource Planning to better account energy, with component-level asset granularity.
Bonino, Dario, Corno, Fulvio, Ferrero, Gianni, Luigi De Russis   +3 more
core   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

Frontiers in Pharmacology
The 2020 FDA drug-drug interaction (DDI) guidance includes a consideration for metabolites with structural alerts for potential mechanism-based inhibition (MBI) and describes how this information may be used to determine whether in vitro studies need to ...
Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya   +6 more
doaj   +1 more source

Toxicological testing of syringaresinol and enterolignans

Current Research in Toxicology, 2020
Lignans are secondary plant constituents with dibenzylbutane skeletons found in cereals, oilseeds, and nuts. Two members of this class, syringaresinol (Syr) and secoisolariciresinol (Seco), occur at relatively high levels in cereals and processed food ...
Verena Kirsch, Tamara Bakuradze, Elke Richling   +2 more
doaj   +1 more source

Synthesis of Homo- and Heterobimetallic Ni\u3csup\u3eII\u3c/sup\u3e–M\u3csup\u3eII\u3c/sup\u3e (M = Fe, Co, Ni, Zn) Complexes Based on an Unsymmetric Ligand Framework: Structures, Spectroscopic Features, and Redox Properties [PDF]

, 2014
Several homo- and heterobimetallic NiII–MII complexes (MII = Fe, Co, Ni, Zn) supported by an unsymmetric polydentate ligand (L13−) are reported (L13− is the trianion of 2-[bis(2-hydroxy-3,5-tert-butylphenyl)aminomethyl]-4-methyl-6-[(2-pyridylmethyl ...
Fiedler, Adam T., Lindeman, Sergey V., Wang, Denan   +2 more
core   +1 more source

Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation—A Case Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT New‐onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%–27% mortality rate and significant long‐term neurological sequelae. Neuromodulation such as deep brain stimulation (DBS) targeting the anterior and centromedian thalamic nuclei has shown promise when the traditional ...
Mengxuan Tang, Amerta Bai, Felipe Rodridgues Marques Ferreira, Sandipan Pati, Thaddeus Walczak, Benjamin Miller, Oladi Bentho, Thomas Henry, Ilo Leppik, Minoo Shams, Zhiyi Sha, Zachary Sanger, Theoden I. Netoff, Thomas Lisko, Anant Naik, Robert McGovern III, Sima Patel   +16 more
wiley   +1 more source

Project Testbed: Argument Mapping and Deliberation Analytics [PDF]

, 2015
One key goal of the Catalyst project was to design metrics that could capture and represent aspects of the conversation’s structural quality, to assist harvesters and moderators. Many such metrics, alerts and visualizations were developed in
De Liddo, Anna, Klein, Marc, Parent, Marc-Antoine, Ullmann, Thomas   +3 more
core  

Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes [PDF]

Chemical Research in Toxicology, 2017
Structural alerts are commonly used in drug discovery to identify molecules likely to form reactive metabolites and thereby become toxic. Unfortunately, as useful as structural alerts are, they do not effectively model if, when, and why metabolism renders safe molecules toxic. Toxicity due to a specific structural alert is highly conditional, depending
Na Le Dang, Tyler B. Hughes, Grover P. Miller, S. Joshua Swamidass   +3 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Oscar Wilde as a temporal designer : a case study of the picture of Dorian Gray [PDF]

, 2015
Since the publication of Oscar Wilde’s The Picture of Dorian Gray, there have been great amounts of ideological criticism both for and against the author and the work.
Behin, Bahram, Khiabani, Mahdiyeh T.
core   +3 more sources