Results 71 to 80 of about 389,935 (259)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Strengthening Klein’s floor slabs with the use of current norms
Budownictwo i Architektura, 2015 The paper presents the effectivity of using the steel-concrete floor slabs in existing buildings. Steel-concrete slabs described in this paper consist of old steel beams which are main structural members of the floor slabs and reinforced concrete slabs ...
Marcin Górecki +1 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
A preliminary study of the nonlinearity of adhesive point-fixings in structural glass facades
Journal of Facade Design and Engineering, 2014 The recent demand for architectural transparency has drastically increased the use of glass material for structural purpose. However, connections between structural glass members represent one of the most critical aspects of glass engineering, due to ...
Jonas Dispersyn +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Issues of contemporary wind engineering and aerodynamics of building structures
Budownictwo i Architektura, 2016 The paper reviews nowadays problems and issues of wind engineering and aerodynamics of building structures. The article mainly focuses on aerodynamics of building structures, shortly characterizing theoretical bases, which one must take into account when
Tomasz Lipecki, Paulina Jamińska
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
The impact of values and modelling method on the static-strength work of a typical scaffolding
Budownictwo i Architektura, 2014 This paper describes the results of static non-linear calculations in reference to a typical building scaffolding, in the case when the scaffolding is operated.
Ewa Błazik-Borowa, Jakub Gontarz
doaj +1 more source
Structure by Architecture: Structured Representations without Regularization
, 2020 We study the problem of self-supervised structured representation learning using autoencoders for downstream tasks such as generative modeling. Unlike most methods which rely on matching an arbitrary, relatively unstructured, prior distribution for sampling, we propose a sampling technique that relies solely on the independence of latent variables ...
Felix Leeb +5 more
openaire +3 more sources