Results 61 to 70 of about 389,935 (259)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Cognitive Architectures for Conceptual Structures [PDF]

, 2011
The book Conceptual Structures: Information Processing in Mind and Machine surveyed the state of the art in artificial intelligence and cognitive science in the early 1980s and outlined a cognitive architecture as a foundation for further research and development.
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Concepts of Architecture, Structure and System

CoRR, 2018
The current ISO standards pertaining to the Concepts of System and Architecture express succinct definitions of these two key terms that lend themselves to practical application and can be understood through elementary mathematical foundations. The current work of the ISO/IEC Working Group 42 is seeking to refine and elaborate the existing standards ...
Michael K. Wilkinson, Charles E. Dickerson, Siyuan Ji   +2 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Component-Based Modeling of Steel–Concrete Composite Endplate Connections Under Fire Conditions

Advances in Civil Engineering
In fire scenarios, the performance of connections in composite structures differs significantly from that in noncomposite steel structures. To accurately simulate the high-temperature behavior of composite endplate connections, a component-based model ...
Yu Liu, Yi-Ze Chai, Shan-Shan Huang, Ian Burgess   +3 more
doaj   +1 more source

The study of the mechanical properties of the porous gypsum

Budownictwo i Architektura, 2015
The paper presents the laboratory test results of the mechanical properties of porous gypsum. Material for the study was obtained from gypsum Pro-Monta plate of 100mm thick.
Jakub Gontarz, Jerzy Podgórski
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Progressive Collapse Test of Ship Structures in Waves

Polish Maritime Research, 2018
The external loads and structural ultimate strength are two important aspects for the safety of ship hull girder. It may collapse in case the structural capacity is less than the external forces in extreme seas.
Pei Zhiyong, Xu Tao, Wu Weiguo
doaj   +1 more source

Determination of tensile strength of concrete and rocks by using the Brazilian test in the confrontation with the failure criteria

Budownictwo i Architektura, 2014
The paper presents the analysis of the Brazilian compression tests considering the possibilities of determining the proper tensile strength. These analyses include the precise designation of the stress field without singularity at the point of ...
Jakub Gontarz, Jerzy Podgórski
doaj   +1 more source