Results 61 to 70 of about 1,267,350 (294)
Holistic Design Explorations of Building Envelopes Supported by Machine Learning
Journal of Facade Design and Engineering, 2021 The design of building envelopes requires a negotiation between qualitative and quantitative aspects belonging to different disciplines, such as architecture, structural design, and building physics.
Federico Bertagna +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Structural Intuition and Creative Play: An Architectural Perspective to Shell Pedagogies [PDF]
, 2016 The notions of structural intuition and creative play had been raised by particular structural artists (Billington, 1983 [1]). Professor Pier Luigi Nervi expressed the importance of Structural Intuition in his 1965 Elliot Norton Lectures at Harvard ...
Tang, Gabriel
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A neural blackboard architecture of sentence structure [PDF]
, 2003 We present a neural architecture for sentence representation. Sentences are represented in terms of word representations as constituents. A word representation consists of a neural assembly distributed over the brain.
de Kamps, dr. Marc +1 more
core
Spectral mapping of brain functional connectivity from diffusion imaging. [PDF]
, 2018 Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience.
Bassett, Danielle S +6 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Materials and techniques of Art Nouveau architecture in Italy and Portugal: a first insight for an European route to consistent restoration [PDF]
, 2009 The results of the investigations on building materials and techniques of Casa Major Pessoa, a typical Art Nouveau construction in Aveiro (Portugal), and two coeval Art Nouveau buildings in Bologna (Italy) are presented as a methodological contribution
Dell’Acqua, A. C. +3 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source