Results 61 to 70 of about 650,868 (292)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Use of designed sequences in protein structure recognition
Biology Direct, 2018 Background Knowledge of the protein structure is a pre-requisite for improved understanding of molecular function. The gap in the sequence-structure space has increased in the post-genomic era.
Gayatri Kumar +3 more
doaj +1 more source
Sensors, 2020 This paper proposes a novel output-only structural damage indicator by incorporating the pole-based optimal subpattern assignment distance with autoregressive models to localize and relatively assess the severity of damages for sheared structures ...
Liu Mei +5 more
doaj +1 more source
Register assignment in tree-structured programs [PDF]
Information Sciences, 1979 Abstract Much complex decision-making is performed routinely by the software of a computer system. It is appropriate to study more thoroughly the performance of this built-in decision-making, because it can strongly influence the efficiency of the entire system.
openaire +3 more sources
Isolation, Structural Assignment, and Total Synthesis of Barmumycin [PDF]
The Journal of Organic Chemistry, 2010 Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. On the basis of preliminary one- and two-dimensional (1)H and (13)C NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later ...
Lorente Crivillé, Adriana +4 more
openaire +3 more sources
On the Epistemology of Modal Rationalism: the Main Problems and Their Significance [PDF]
, 2015 In this paper, I discuss the main characteristics of the epistemology of modal rationalism by proceeding from the critical investigation of Peacocke’s theory of modality.
Rusu, Mihai
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6- (3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one [PDF]
, 2018 Natural and semi-synthetic compounds are being studied as novel phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction, pulmonary hypertension, and lower urinary symptoms.
Ongaro, Alberto +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Frontiers in Public HealthPrior to a fall semester graduate course in public health, students are encouraged to complete a summer reading assignment based on a book chosen from a curated list of popular literature relevant to public health concepts.
Donna J. Petersen
doaj +1 more source