Results 91 to 100 of about 273,506 (260)

Understanding barriers to well-child visit attendance among racial and ethnic minority parents

BMC Primary Care
Objectives To assess racial and ethnic minority parents’ perceptions about barriers to well-child visit attendance. Methods For this cross-sectional qualitative study, we recruited parents of pediatric primary care patients who were overdue for a well ...
Nisha Fahey, Allison Holt, Deniz Cataltepe, Annelise Brochier, Amy Stern, Morgan Mazanec, James W. Courtemanche, Tracey Wilkie, Kellie Tan, Rulan Lyu, Eric Alper, Josephine Fowler, Lawrence Rhein, Arvin Garg   +13 more
doaj   +1 more source

The Obstacles Finding Pattern for Bank's Strategic Marketing [PDF]

مطالعات مدیریت راهبردی, 2016
Research on the implementation of marketing plans does not in line with marketing formulation and despite design qualitative and quantitative tools and comprehensive model to strategy formulation, a few number of research activities have been considering
Asghar Moshabaki, Nina Pourebrahimi
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Structural and cultural barriers to patient education from the perspective of Iranian nurses: a qualitative study

BMC Nursing
Aim This study examines the structural and cultural barriers that hinder patient education (PE) among nurses in Iranian public hospitals, focusing on the unique challenges in Hamadan’s healthcare system.
Safura Yaghmaei, Nazanin Rajabi Kahrizi, Zahra Ranjipour, Shiva Gomarverdi, Fariba Tayebi Arasteh, Zeinab Mosivand, Roya Ghahremani   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Transportation, administrative burden, and COVID-19: A structural intersectional analysis of barriers to HIV care among Black sexual minority men living with HIV in the US South

SSM: Qualitative Research in Health
While much research has focused on individual (e.g., mental health, substance use) and structural factors (e.g., stigma, institutional racism) driving HIV inequities, less studied are the macro-structural factors like policies governing healthcare and ...
Chadwick K. Campbell, Hannah E. Reynolds, Kirstin Kielhold, Daniel E. Siconolfi, Stephen D. Ramos, Susan M. Kegeles, Erik D. Storholm   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source