Results 71 to 80 of about 273,506 (260)
Cleats on, battle real: sustainability and gender equality in women’s football
ObjectiveThis study aims to examine the rise of women’s football in Turkey and the challenges faced by female footballers both on and off the field from the perspectives of gender and sustainability.MethodsConducted with a phenomenological design, the ...
Serda Ornek +4 more
doaj +1 more source
Contemporary society is moving from traditional viewpoints to modern settings. The characteristic of the transitional period is the chaos evolved regarding the general state of affairs as well as both the behavioral and thought developments in a given ...
Shohreh Shahsavari Fard
doaj
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Predictors of young people's healthcare access in the digital age
Objective: To quantify barriers to healthcare for young people (12–24 years) and identify socio‐demographic correlates and predictors. Methods: This cross‐sectional survey targeted young people living in New South Wales, Australia, with oversampling of ...
Fiona Robards +8 more
doaj +1 more source
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Evaluating the role of economic management in improving and expanding Iranian sports facilities and equipment [PDF]
This research evaluates the role of economic management in improving and expanding sports facilities in Iran. This is an applied research conducted with a mixed approach.
Mohammad saeid Kiani, Leila Nazari
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source

