Results 91 to 100 of about 1,910,238 (232)
Nature CommunicationsProtein O-mannosyltransferases (PMTs) add mannose to serine/threonine (S/T)-rich proteins in the endoplasmic reticulum, facilitating proper folding and trafficking through the secretory pathway.
Minge Du +4 more
doaj +1 more source
Speckle-modulating optical coherence tomography in living mice and humans
Nature Communications, 2017 Optical coherence tomography, a technique that can image inside tissue, is susceptible to speckle noise that limits its diagnostic potential. Here, Libaet al.
Orly Liba +7 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Heliyon, 2019 Three Australian native Eucalyptus species, i.e., Eucalyptus woodwardii, Eucalyptus pachyphylla and Eucalyptus dolorosa, were investigated, for the first time, with respect to the hydrophobicity of their leaves.
Hua Guo +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]
, 2018 Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Szerkezeti biológia = Structural biology [PDF]
, 2011 Kiroptikai spektroszkópia (ECD, VCD) - Az abszolút konfiguráció meghatározása - Gyűrűs és lineáris peptid modellek konformációjának meghatározása - Királis diródium komplexek ECD és VCD vizsgálata Fehérje NMR és modellezés - Peptidek ...
Farkas, Viktor +15 more
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