Results 101 to 110 of about 5,504,723 (310)
The structural biology of PRRSV
Virus Research, 2010 Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, positive-sense single-stranded RNA virus belonging to the Arteriviridae family. Arteriviruses and coronaviruses are grouped together in the order Nidovirales, based on similarities in genome organization and expression strategy.
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Diffraction Techniques in Structural Biology [PDF]
Current Protocols in Nucleic Acid Chemistry, 2010 AbstractA detailed understanding of chemical and biological function and the mechanisms underlying the molecular activities ultimately requires atomic‐resolution structural data. Diffraction‐based techniques such as single‐crystal X‐ray crystallography, electron microscopy, and neutron diffraction are well established and they have paved the road to ...
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Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]
, 2013 A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos +2 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Structural Biology and Drug Design
, 2015 The discovery of new drugs is a time and labor-intensive process. On average, the discovery of a new drug requires the preparation and evaluation of approximately 10,000 compounds over 12 years at a cost of more than $350 million.
Doriano Lamba
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology [PDF]
, 2010 Conventional drug design embraces the "one gene, one drug, one disease" philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery.
Durrant, Jacob D. +10 more
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Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation
Communications ChemistryThe aggregation of the tau protein into intraneuronal fibrillar tangles is closely associated with the pathology of Alzheimer’s disease. The endogenous defense system against this process includes molecular chaperones, among which DNAJB6b has emerged as ...
Andreas Carlsson +5 more
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Structural and cellular biology of Teneurins and other neuronal cell adhesion receptors
The development of the nervous system is a complicated process that rests on correct cell migration and cell-to-cell (trans) communication. These in turn rely on cell adhesion molecules which perform most of the interactions happening during these ...
Berbeira Santana, Miguel
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, 2023 This course covers a detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. The topics covered in lectures and readings of relevant literature include gene regulation,
Faculty, Biology Department
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