Results 91 to 100 of about 5,504,723 (310)

The future of integrated structural biology [PDF]

Instruct-ERIC, "the European Research Infrastructure Consortium for Structural biology research," is a pan-European distributed research infrastructure making high-end technologies and methods in structural biology available to users.
Sussman, Joel L., Carugo, K.D., Haley, Natalie, Hart, Darren J, Schwalbe, H., Celie, Patrick, Baumeister, W., Felli, Isabella, Carugo, Kristina Djinovic, Pierattelli, Roberta, Trantirek, Lukas, Lindorff-Larsen, Kresten, Sussman, J., Rosato, A., Banci, Lucia, Hauß, T., Weiss, Manfred, Celie, P., Pierattelli, R., Steyaert, Jan, Carazo, Jose Maria, Sreeramulu, S., Baldus, M., Haley, N., Wilmanns, M., Carazo, J., Lehtiö, Lari, Carazo, J M, Carugo, K., Matagne, André, Sussman, Joel, Márquez, J., Audergon, P., Steyaert, J., Agirre, Jon, Baumeister, Wolfgang, Banci, L., Agirre, J., Wilmanns, Matthias, Amaro, C.A., Weiss, Manfred S., Lehtiö, L., Lindorff-Larsen, K., Sobott, F., Schwalbe, Harald, Weiss, M.S., Márquez, José, Carazo, J.M., Amaro, C., Hart, D., Audergon, Pauline, Hart, Darren J., Trantirek, L., Blackledge, M., Amaro, Claudia Alen, Baldus, Marc, Hauß, Thomas, Sussman, J.L., Rosato, Antonio, Matagne, A., Weiss, Manfred S, Hart, Darren, Sussman, Joel L, Felli, I., Sobott, Frank, Sreeramulu, Sridhar, Hart, D.J., Blackledge, Martin, Weiss, M.   +68 more
core   +1 more source

Unique structural features of the Mycobacterium ribosome

, 2020
Protein synthesis in all the living cells is mediated by a large protein-RNA complex called the ribosome. These macromolecular complexes can range from 2.5 (prokaryotes) to 4.2 MDa.
Kushwaha, Ambuj Kumar, Bhushan, Shashi
core   +1 more source

Structural biology with carbon nanotube AFM probes [PDF]

, 2000
Carbon nanotubes represent ideal probes for high-resolution structural and chemical imaging of biomolecules with atomic force microscopy. Recent advances in fabrication of carbon nanotube probes with sub-nanometer radii promise to yield unique insights ...
Hafner, Jason H., Lieber, Charles, Lieber, Charles M., Cheung, Chin Li, Woolley, Adam T., Lieber, Charles M, Woolley, Adam T, Hafner, Jason H   +7 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Deciphering a global network of functionally associated post‐translational modifications

Molecular Systems Biology, 2012
Various post‐translational modifications (PTMs) fine‐tune the functions of almost all eukaryotic proteins, and co‐regulation of different types of PTMs has been shown within and between a number of proteins.
Pablo Minguez, Luca Parca, Francesca Diella, Daniel R Mende, Runjun Kumar, Manuela Helmer‐Citterich, Anne‐Claude Gavin, Vera van Noort, Peer Bork   +8 more
doaj   +1 more source

Comment on 'The structural relationship: regression in biology'

, 2010
Supplementary information relevant to structural relationship regression in biology as discussed by McArdle (1988; Can. J. Zool. 66(11): 2329–2339) is presented.
M. S. Dhanoa, R. Sanderson, Dhanoa, M. S., Sanderson, R.   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ

, 2019
In contrast to other prokaryotes, the Mycobacterial F1FO ATP synthase (α3:β3:γ:δ:ε:a:b:b’:c9) is essential for growth. The mycobacterial enzyme is also unique as a result of its 111 amino acids extended δ subunit, whose gene is fused to the peripheral ...
Bond, Peter J., Kamariah, Neelagandan, Grüber, Gerhard, Nartey, Wilson, Huber, Roland G., Bhushan, Shashi   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs

Communications Biology
Short Linear Motifs (SLiMs) play a pivotal role in the interactions between intrinsically disordered proteins and their binding partners. SLiMs can undergo regulation through post-translational modifications, including phosphorylation.
Mattia Utichi, Oana N. Antonescu, Valentina Sora, Henri-Baptiste Marjault, Matteo Tiberti, Emiliano Maiani, Matteo Lambrughi, Elena Papaleo   +7 more
doaj   +1 more source