Results 81 to 90 of about 1,927,181 (199)

Structural Biology of Zinc

, 1991
The biological function of zinc is governed by the composition of its tetrahedral coordination polyhedron in the metalloprotein, and each ligand group that coordinates to the metal ion does so with a well-defined stereochemical preference. Consequently, protein-zinc recognition and discrimination requires proper chemical composition and proper ...
openaire   +2 more sources

The structure and biology of insulin [PDF]

Biochemical Journal, 1971
T L, Blundell, J F, Cutfield, G G, Dodson, E, Dodson, D C, Hodgkin, D, Mercola   +5 more
openaire   +2 more sources

The MCU and MCUb amino-terminal domains tightly interact: mechanisms for low conductance assembly of the mitochondrial calcium uniporter complex

iScience
Summary: The mitochondrial calcium (Ca2+) uniporter (MCU) complex is regulated via integration of the MCU dominant negative beta subunit (MCUb), a low conductance paralog of the main MCU pore forming protein.
Megan Noble, Danielle M. Colussi, Murray Junop, Peter B. Stathopulos   +3 more
doaj   +1 more source

High-Z Nanoparticle Tagging in Cryo-STEM for Localisation in Cryo-ET: Theory and Damage [PDF]

BIO Web of Conferences
Bowles William, Velazco-Torrejon Abner, Ramadurai Siva, Gallagher-Jones Marcus, Kirkland Angus, Siebert Alistair, Naismith James, Dumoux Maud   +7 more
doaj   +1 more source

Evolutionary descent of prion genes from a ZIP metal ion transport ancestor [PDF]

, 2009
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic.
David Westaway, Gerold Schmitt-Ulms, Holger Wille, Joel C. Watts, Sepehr Ehsani   +4 more
core   +1 more source

Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics

Scientific Reports
The COVID-19 disease is an ongoing global health concern. Although vaccination provides some protection, people are still susceptible to re-infection. Ostensibly, certain populations or clinical groups may be more vulnerable.
Vaishali P. Waman, Paul Ashford, Su Datt Lam, Neeladri Sen, Mahnaz Abbasian, Laurel Woodridge, Yonathan Goldtzvik, Nicola Bordin, Jiaxin Wu, Ian Sillitoe, Christine A. Orengo   +10 more
doaj   +1 more source

The p53 mRNA exhibits riboswitch-like features under DNA damage conditions

iScience
Summary: RNA riboswitch structures control prokaryotic gene expression in response to changes in the cellular environment, but how this concept has evolved in mammalian cells is yet little known.
Sa Chen, Lixiao Wang, Laurence Malbert-Colas, Konstantinos Karakostis, Vanesa Olivares-Illana, Sivakumar Vadivel Gnanasundram, Robin Fahraeus   +6 more
doaj   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Scientific Reports
Despite their high clinical relevance, obtaining structural and biophysical data on transmembrane proteins has been hindered by challenges involved in their expression and extraction in a homogeneous, functionally-active form.
Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze   +7 more
doaj   +1 more source

A celebration of structural biology [PDF]

Nature Methods, 2021
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