Results 71 to 80 of about 5,504,723 (310)

Protein domain boundary predictions: a structural biology perspective

, 2009
One of the important fields to apply computational tools for domain boundaries prediction is structural biology. They can be used to design protein constructs that must be expressed in a stable and functional form and must produce diffraction-quality ...
Sampath Ranjan, Sureshkumar (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Kumar, Suresh (Max F. Perutz Laboratories), CARUGO, OLIVIERO ITALO, Oliviero Carugo, Suresh Kumar, Kirillova S, Carugo, Oliviero (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Svetlana Kirillova, Kirillova, Svetlana (Max F. Perutz Laboratories), Kumar S   +9 more
core   +1 more source

Towards a structural biology work bench [PDF]

, 2013
This is an introduction to four papers based on presentations given at a workshop entitled Integrated Software for Integrative Structural Biology. The use of hybrid techniques, and other trends in structural research, pose new challenges to software ...
Morris C, Chris Morris
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Nature Communications, 2020
Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF ...
Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg   +6 more
doaj   +1 more source

Neutron structural biology

Journal of Physics and Chemistry of Solids, 1999
Hydrogen atoms and water molecules around proteins and nucleic acids play a crucial role in many physiological functions. Neutron diffraction provides an experimental method of directly locating hydrogen atoms. (a) Since almost all the H atom positions can be identified experimentally, the geometrical details of certain types of H-bonds can be ...
openaire   +3 more sources

Structural biology and cancer [PDF]

BMC Proceedings, 2013
The techniques of structural biology currently play an important role in the development of novel therapeutic agents including cancer chemotherapies. X-ray crystallography has proved to be a particularly powerful tool for both the discovery of novel compounds and their subsequent development.
openaire   +2 more sources

Structural biology of the p53 tumour suppressor

, 2009
The p53 tumour suppressor protein has presented a challenge for structural biology for more than two decades. The complete p53 molecule has eluded numerous attempts to determine its structure, presumably owing to the intrinsic conformational flexibility ...
Andrei L Okorokov, Elena V Orlova, Okorokov, A.L., Orlova, Elena   +3 more
core   +1 more source

Responses to`Atomic resolution': a badly abused term in structural biology [PDF]

, 2017
The Editors of Acta Cryst. D have received a Letter to the Editor from Alex Wlodawer and Zbigniew Dauter (Wlodawer & Dauter, 2017[Wlodawer, A. & Dauter, Z. (2017). Acta Cryst. D73, 379-380.]) concerning the use of the term atomic resolution.
Schlichting, I., Jennifer L Martin, Martin, Jennifer L, Read, Randy J, Sauter, NK, Schlichting, I, Langan, P., Holton, J, Chiu, Wah, Wah Chiu, Soichi Wakatsuki, Terwilliger, Tom, Holton, J., Randy J. Read, Terwilliger, T, Read, R., Schlichting, Ilme, Holton, James, Langan, P, Tom Terwilliger, Martin, J., Paul Langan, Sauter, N., Wakatsuki, Soichi, Chiu, W, Ilme Schlichting, Terwilliger, T., James Holton, Langan, Paul, Read, RJ, Chiu, W., Wakatsuki, S., Nicholas K. Sauter, Sauter, Nicholas K, Martin, JL, Wakatsuki, S   +35 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging

Scientific Reports, 2019
Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative tumor margin ...
Derek Yecies, Orly Liba, Elliott D. SoRelle, Rebecca Dutta, Edwin Yuan, Hannes Vogel, Gerald A. Grant, Adam de la Zerda   +7 more
doaj   +1 more source