Results 71 to 80 of about 1,910,238 (232)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Structural basis of thiamine transport and drug recognition by SLC19A3
Nature CommunicationsThiamine (vitamin B1) functions as an essential coenzyme in cells. Humans and other mammals cannot synthesise this vitamin de novo and thus have to take it up from their diet.
Florian Gabriel +7 more
doaj +1 more source
Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]
, 2020 Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
core +1 more source
Principles of protein structure: An established Internet‐based course in structural biology [PDF]
, 2000 The Department of Crystallography at Birkbeck College, London, UK, has been running a one‐year, part‐time accredited graduate course, ‘Principles of Protein Structure’, entirely over the Internet since 1996.
Moss, David, Sansom, Clare
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Systematic identification of proteins that elicit drug side effects
Molecular Systems Biology, 2013 Side effect similarities of drugs have recently been employed to predict new drug targets, and networks of side effects and targets have been used to better understand the mechanism of action of drugs.
Michael Kuhn +6 more
doaj +1 more source
The review of recent advances in fish genetics and biotechnology [PDF]
, 2012 Great advances have been, and are being made in our knowledge of the genetics and molecular biology (including genomics, proteomics and structural biology).
Mgbabu , Christopher Nwokwa
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural ultrafast dynamics of macromolecules: diffraction of free DNA and effect of hydration [PDF]
, 2009 Of special interest in molecular biology is the study of structural and conformational changes which are free of the additional effects of the environment.
Lin, Milo M. +2 more
core +1 more source