Results 61 to 70 of about 3,581,851 (300)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Forecast Combinations in the Presence of Structural Breaks: Evidence from U.S. Equity Markets
Mathematics, 2018 Realized volatility, building on the theory of a simple continuous time process, has recently received attention as a nonparametric ex-post estimate of the return variation. This paper addresses the problem of parameter instability due to the presence of
Davide De Gaetano
doaj +1 more source
HIGHWAY AND RAILWAY INFRASTRUCTURE, REAL INCOME AND STRUCTURAL BREAKS [PDF]
Modern Management Review, 2013 Infrastructure systems affect economic development directly or indirectly depending on their structure, type, quality and quantity. Transportation infrastructure is one of the most important types of infrastructure systems since the improvements in ...
Mehmet Aldonat BEYZATLAR +1 more
doaj +1 more source
Ice breaking in GPCR structural biology [PDF]
Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs) are one of the most challenging targets in structural biology. To successfully solve a high-resolution GPCR structure, several experimental obstacles must be overcome, including expression, extraction, purification, and crystallization.
Qiang, Zhao, Bei-li, Wu
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Real Time Detection of Structural Breaks in GARCH Models [PDF]
A sequential Monte Carlo method for estimating GARCH models subject to an unknown number of structural breaks is proposed. Particle filtering techniques allow for fast and efficient updates of posterior quantities and forecasts in real time.
John M. Maheu, Zhongfang He
core +2 more sources
Unit Root Tests and Structural Breaks: A Survey with Applications||Contrastes de raíces unitarias y cambios estructurales: un estudio con aplicaciones [PDF]
Revista de Métodos Cuantitativos para la Economía y la Empresa, 2007 The theme of unit roots in macroeconomic time series have received a great amount of attention in terms of theoretical and applied research over the last three decades.
Verma, Reetu +2 more
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source