Results 101 to 110 of about 4,034,259 (329)

Application of design sensitivity analysis for greater improvement on machine structural dynamics [PDF]

Methodologies are presented for greatly improving machine structural dynamics by using design sensitivity analyses and evaluative parameters. First, design sensitivity coefficients and evaluative parameters of structural dynamics are described. Next, the
Yoshimura, Masataka
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Screw pull-out force predictions in porcine radii using efficient nonlinear µFE models including contact and pre-damage

Frontiers in Bioengineering and Biotechnology
Nonlinear micro finite element (µFE) models have become the gold-standard for accurate numerical modeling of bone-screw systems. However, the detailed representation of bone microstructure, along with the inclusion of nonlinear material and contact, and ...
Pia Stefanek, J. D. Silva-Henao, J. D. Silva-Henao, Victoria Fiedler, A. G. Reisinger, A. G. Reisinger, Dieter H. Pahr, Alexander Synek   +7 more
doaj   +1 more source

Approximation methods for combined thermal/structural design [PDF]

Two approximation concepts for combined thermal/structural design are evaluated. The first concept is an approximate thermal analysis based on the first derivatives of structural temperatures with respect to design variables.
Haftka, R. T., Shore, C. P.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Edge Strength of Annealed Float Glass: Influence and Optimization of Cutting Process Parameters

Challenging Glass Conference Proceedings, 2022
The desire to apply annealed float glass with their economic and optical advantages is limited by the reduced edge strength due to the cutting process. The edge strength of annealed float glass is a decisive factor especially for insulating glazing due ...
Matthias Seel, Steffen Müller-Braun, Peter Hof, Jens Schneider, Matthias Oechsner   +4 more
doaj  

Composite fuselage technology (summary of year 2) [PDF]

The overall objective of this work is to identify and understand, via directed experimentation and analysis, the mechanisms which control the structural behavior of fuselages in their response to damage (resistance, tolerance, and arrest).
Graves, Michael J., Lagace, Paul A.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Structural Design and Performance Analysis of α Particle Micro-thruster [PDF]

, 2019
Fei Xu, Yan Xia, Shiyi He, Wenlei Xiao, Xiaoping Ouyang, Guoqing Liu   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source