Results 81 to 90 of about 4,022,588 (277)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Structural design for dynamic response reduction [PDF]
A computer program for redesigning structural modes to reduce response has been initiated. The linear regulator approach in modal coordinates has been implemented.
Hanks, B. R.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Challenging Glass Conference Proceedings, 2018 Laminated safety glass has become an indispensable component in building construction, automotive and solar industry. It consists of at least two glass panes, that are laminated together with a polymeric interlayer.
Miriam Schuster +3 more
doaj +1 more source
Titanium and advanced composite structures for a supersonic cruise arrow wing configuration [PDF]
Structural design studies were made, based on current technology and on an estimate of technology to be available in the mid 1980's, to assess the relative merits of structural concepts and materials for an advanced arrow wing configuration cruising at ...
Hoy, J. M., Turner, M. J.
core +1 more source
Exploratory study into a safety format for composite columns exposed to fire [PDF]
, 2019 Current performance based structural fire engineering approaches evaluate structural behaviour under prescribed fire scenarios. The mechanical properties of the materials, the load conditions and geometric parameters are all however fraught with ...
Elhami Khorasani, Negar +3 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Design optimization applied in structural dynamics [PDF]
, 2007 This paper introduces the design optimization strategies, especially for structures which have dynamic constraints. Design optimization involves first the modeling and then the optimization of the problem.
Akcay Perdahcioglu, Didem +2 more
core +1 more source