Results 41 to 50 of about 107,582 (301)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Chemistry of the Nudibranch <em>Aldisa andersoni</em>: Structure and Biological Activity of Phorbazole Metabolites

Marine Drugs, 2012
The first chemical study of the Indo-Pacific dorid nudibranch <em>Aldisa andersoni</em> resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and <
Guido Cimino, Margherita Gavagnin, Florence Lefranc, Lisette D’Souza, Ernesto Mollo, Guido Villani, Emiliano Manzo, Helene Leclercqz, Robert Kiss, Véronique Mathieu, Maria Letizia Ciavatta, Genoveffa Nuzzo   +11 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral <em>Sinularia</em> sp. and Their Antifouling Activity

Marine Drugs, 2012
Nine new compounds, namely sinularones A–I (<strong>1</strong>–<strong>9</strong>), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral <em>Sinularia</em> sp., together with a
Leen van Ofwegen, Wenhan Lin, Peter Proksch, Shanjiang Yu, Dong Liu, Haiyan Shi   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae

Marine Drugs, 2014
Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (1–6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae.
Zehong Wu, Dong Liu, Peter Proksch, Peng Guo, Wenhan Lin   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Synthesis and NMR elucidation of homoisoflavanone analogues

, 2010
A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported.
Mahidansha Shaikh, Kruger, HG, Katja Petzold, Hendrik G. Kruger, Karen du Toit, Shaikh, M, Petzold, Katja,, du Toit, K   +7 more
core   +1 more source

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Journal of the American Chemical Society, 2023
Queuosine is one of the most complex hypermodified RNA nucleosides found in the Wobble position of tRNAs. In addition to Queuosine itself, several further modified derivatives are known, where the cyclopentene ring structure is additionally modified by a galactosyl-, a mannosyl-, or a glutamyl-residue.
Pichler, Alexander, Hillmeier, Markus, Heiss, Matthias, Peev, Elsa, Xefteris, Stylianos, Steigenberger, Barbara, Thoma, Ines, Müller, Markus, Borsò, Marco, Imhof, Axel, Carell, Thomas   +10 more
openaire   +4 more sources