Results 41 to 50 of about 3,458,614 (298)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Chemistry of the Nudibranch <em>Aldisa andersoni</em>: Structure and Biological Activity of Phorbazole Metabolites

Marine Drugs, 2012
The first chemical study of the Indo-Pacific dorid nudibranch <em>Aldisa andersoni</em> resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and <
Guido Cimino, Margherita Gavagnin, Florence Lefranc, Lisette D’Souza, Ernesto Mollo, Guido Villani, Emiliano Manzo, Helene Leclercqz, Robert Kiss, Véronique Mathieu, Maria Letizia Ciavatta, Genoveffa Nuzzo   +11 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral <em>Sinularia</em> sp. and Their Antifouling Activity

Marine Drugs, 2012
Nine new compounds, namely sinularones A–I (<strong>1</strong>–<strong>9</strong>), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral <em>Sinularia</em> sp., together with a
Leen van Ofwegen, Wenhan Lin, Peter Proksch, Shanjiang Yu, Dong Liu, Haiyan Shi   +5 more
doaj   +1 more source

Purification and identification of oligosaccharides from Cimicifuga heracleifolia Kom. rhizomes

Food Chemistry: X, 2023
Even though Cimicifuga sp. is widely used in functional foods around the world, the content and structure of its oligosaccharides remain unclear. Here, we isolated a mixture of oligosaccharides from Cimicifuga heracleifolia Kom.
Liangnan Cui, Jing Wu, Xiang Wang, Xiaotong Yang, Zixin Ye, Kevin H. Mayo, Lin Sun, Yifa Zhou   +7 more
doaj   +1 more source

Structure elucidation of colibactin [PDF]

, 2019
Abstract Colibactin is a gut microbiome metabolite of unknown structure that has been implicated in colorectal cancer formation. Several studies now suggest that the tumorgenicity of colibactin derives from interstrand cross-linking of host DNA.
Xue, Mengzhao, Kim, Chung Sub, Healy, Alan R., Wernke, Kevin M., Wang, Zhixun, Frischling, Madeline C., Shine, Emilee E., Wang, Weiwei, Herzon, Seth B., Crawford, Jason M.   +9 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and structural characterisation of olfactomedin-1 variants as tools for functional studies [PDF]

, 2019
Background Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function.
Sub Crystal and Structural Chemistry, Van den Hoek, H., Crystal and Structural Chemistry, Janssen, Bert J. C., Pronker, M., Van Den Hoek, Hugo, Janssen, B., Pronker, Matti F.   +7 more
core   +2 more sources

Combined Tandem Mass Spectrometry and Computational Chemistry for Structural Elucidation of Singly and Doubly Deprotonated Galac

, 2023
Using experimental and theoretical techniques for structural elucidation of acidic ...
Bataineh, Ola
core   +2 more sources