Results 61 to 70 of about 234,776 (300)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral <em>Sinularia</em> sp. and Their Antifouling Activity

Marine Drugs, 2012
Nine new compounds, namely sinularones A–I (<strong>1</strong>–<strong>9</strong>), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral <em>Sinularia</em> sp., together with a
Leen van Ofwegen, Wenhan Lin, Peter Proksch, Shanjiang Yu, Dong Liu, Haiyan Shi   +5 more
doaj   +1 more source

Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. [PDF]

, 2017
Natural product screening programs have uncovered molecules from diverse natural sources with various biological activities and unique structures. However, much is yet underexplored and additional information is hidden in these exceptional collections ...
Ackermann, Gail, Alexandrov, Theodore, Amir, Amnon, Bandeira, Nuno, Dorrestein, Pieter C, Duggan, Brendan M, Garg, Neha, Gerwick, Lena, Gerwick, William H, Glukhov, Evgenia, Knight, Rob, Luzzatto-Knaan, Tal, Peng, Yao, Ryazanov, Sergey, Wang, Mingxun   +14 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Bioactivity-guided mass spectral net working reveals a new set of allbicidin derivatives from Xanthomonas albilineans [PDF]

, 2016
Albicidin is produced by the sugarcane pathogenic bacterium Xanthomonas albilineans and is a potent antibiotic specifically targeting the bacterial DNA gyrase with an IC50 value in the nanomolar range.
Cociancich, Stéphane, Dang, Tam, Dorrestein, Pieter C., Pesic, Alexander, Petras, Daniel, Royer, Monique, Süssmuth, Roderich   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae

Marine Drugs, 2014
Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (1–6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae.
Zehong Wu, Dong Liu, Peter Proksch, Peng Guo, Wenhan Lin   +4 more
doaj   +1 more source

Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics [PDF]

, 2017
Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow.
Armitage, Emily Grace, Barbas, Coral, Gil de la Fuente, Alberto, Godzien, Joanna, Otero, Abraham   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Isolation, Identification, Anti-Inflammatory, and In Silico Analysis of New Lignans from the Resin of Ferula sinkiangensis

Pharmaceuticals, 2023
Ferula sinkiangensis K. M. Shen (Apiaceae) is distributed in arid desert areas of Xinjiang, and its resin is a traditional Chinese medicine to treat gastrointestinal digestive diseases. To explore bioactive components from F.
Junchi Wang, Qi Zheng, Minghui Shi, Huaxiang Wang, Congzhao Fan, Guoping Wang, Yaqin Zhao, Jianyong Si   +7 more
doaj   +1 more source