Results 51 to 60 of about 107,582 (301)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Isolation, Identification, Anti-Inflammatory, and In Silico Analysis of New Lignans from the Resin of Ferula sinkiangensis

Pharmaceuticals, 2023
Ferula sinkiangensis K. M. Shen (Apiaceae) is distributed in arid desert areas of Xinjiang, and its resin is a traditional Chinese medicine to treat gastrointestinal digestive diseases. To explore bioactive components from F.
Junchi Wang, Qi Zheng, Minghui Shi, Huaxiang Wang, Congzhao Fan, Guoping Wang, Yaqin Zhao, Jianyong Si   +7 more
doaj   +1 more source

Structure elucidation of colibactin [PDF]

, 2019
Abstract Colibactin is a gut microbiome metabolite of unknown structure that has been implicated in colorectal cancer formation. Several studies now suggest that the tumorgenicity of colibactin derives from interstrand cross-linking of host DNA.
Xue, Mengzhao, Kim, Chung Sub, Healy, Alan R., Wernke, Kevin M., Wang, Zhixun, Frischling, Madeline C., Shine, Emilee E., Wang, Weiwei, Herzon, Seth B., Crawford, Jason M.   +9 more
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Identified species and their CID products for structural elucidation.

, 2014
Identified species and their CID products for structural elucidation.
Mônica S. Ferreira (530633), Diogo N. de Oliveira (530632), Rodrigo R. Catharino (288567)   +2 more
core   +1 more source

An efficient computer-aided structural elucidation strategy for mixtures using an iterative dynamic programming algorithm

Journal of Cheminformatics, 2017
The identification of chemical structures in natural product mixtures is an important task in drug discovery but is still a challenging problem, as structural elucidation is a time-consuming process and is limited by the available mass spectra of known ...
Bo-Han Su, Meng-Yu Shen, Yeu-Chern Harn, San-Yuan Wang, Alioune Schurz, Chieh Lin, Olivia A. Lin, Yufeng J. Tseng   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Spectral Analysis and Structural Elucidation of Besifloxacin Hydrochloride

Chinese Journal of Magnetic Resonance, 2018
The ultraviolet spectra (UV), infrared spectra (IR), mass spectra (MS) and nuclear magnetic resonance (NMR) spectra (i.e., 1H NMR, 13C NMR, DEPT, HSQC, HMBC, COSY and NOESY) of besifloxacin hydrochloride were acquired and interpreted.
ZHANG Ming-guang, FENG Xiao-hu, YU Shui-tao, JI Xiao-long, CHEN Zai-xin   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Chromatographic Separation of the Codonocarpine Type Alkaloids from the Root Bark of Capparis decidua

Bio-Protocol, 2017
Various parts of the caper tree Capparis decidua have found application in traditional medicine. The isolation and structural elucidation of the codonocarpine type alkaloids contained in the root bark, however, is not trivial and has probably led to ...
Yvonne Forster, Abdul Ghaffar, Stefan Bienz   +2 more
doaj   +1 more source