Results 91 to 100 of about 2,389,484 (283)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Glass Structures & Engineering Papers
Challenging Glass Conference Proceedings, 2016 Challenging Glass Conference Proceedings, Vol.
openaire +2 more sources
Properties and performance of high strength fibre reinforced concrete by using steel and polypropylene fibres [PDF]
, 2019 Many reinforced concrete structures suffer severe degradation due to the effect from freezing and thawing, shrinkage and expansion, aggressive environment, earthquake and drastic increase of live loads.
Wan Jusoh, Wan Amizah
core
From individual behaviour to an evaluation of the collective evolution of crowds along footbridges
, 2016 This paper proposes a crowd dynamic macroscopic model grounded on microscopic phenomenological observations which are upscaled by means of a formal mathematical procedure.
Bruno, Luca +2 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Probabilistic simulation of the human factor in structural reliability [PDF]
Many structural failures have occasionally been attributed to human factors in engineering design, analyses maintenance, and fabrication processes. Every facet of the engineering process is heavily governed by human factors and the degree of uncertainty ...
Chamis, Christos C., Shah, Ashwin R.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Designing and constructing corrugated glass facades
Journal of Facade Design and Engineering, 2014 Flat glass panels are in use since the time of the Roman Empire. In the ruins of the city of Pompeii, destroyed by the Vulcan Vesuvius in 79 DC, a glass panel in a bronze frame of 300×600mm was found.
Rob Nijsse, Ronald Wenting
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source