Results 91 to 100 of about 7,967,291 (404)

Engineering protein-based therapeutics through structural and chemical design

Nature Communications, 2023
Ebrahimi and Samanta review the key advances in the chemical and structural modification of proteins that have enabled their rise as indispensable tools in medicine and outline emerging protein engineering strategies that can potentially unlock ...
Sasha B. Ebrahimi, Devleena Samanta
semanticscholar   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, Volume 599, Issue 8, Page 1159-1168, April 2025.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

The mathematical components of engineering expertise: the relationship between doing and understanding mathematics [PDF]

, 2002
this paper are extracts from our interviews with engineers.) Where, then, is the complex mathematics that certainly exists in modern engineering? Throughout all aspects of engineering design, computer software has an overwhelming presence.
Kent, Phillip, Noss, Richard
core   +2 more sources

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Shape Memory Alloys for Self-Centering Seismic Applications: A Review on Recent Advancements

Machines
Shape memory alloys (SMAs) have emerged as promising materials for self-centering seismic applications due to their unique properties of superelasticity and shape memory effect. This review article examines recent advancements in the use of SMAs for self-
Girolamo Costanza, Samuel Mercuri, Ilaria Porroni, Maria Elisa Tata   +3 more
doaj   +1 more source

Electrochemical CO2 Reduction on Cu: Synthesis‐Controlled Structure Preference and Selectivity

Advanced Science, 2021
The electrochemical CO2 reduction reaction (ECO2RR) on Cu catalysts affords high‐value‐added products and is therefore of great practical significance. The outcome and kinetics of ECO2RR remain insufficient, requiring essentially the optimized structure ...
Weiwei Quan, Yingbin Lin, Yongjin Luo, Yiyin Huang   +3 more
doaj   +1 more source

Boosting quantum battery performance by structure engineering [PDF]

arXiv, 2021
Quantum coherences, correlations and collective effects can be harnessed to the advantage of quantum batteries. Here, we introduce a feasible structure engineering scheme that is applicable to spin-based open quantum batteries. Our scheme, which builds solely upon a modulation of spin energy gaps, allows engineered quantum batteries to exploit spin ...
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, Volume 599, Issue 9, Page 1269-1284, May 2025.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source