Results 101 to 110 of about 2,389,484 (283)

Total and selective reuse of Krylov subspaces for the resolution of sequences of nonlinear structural problems

, 2012
This paper deals with the definition and optimization of augmentation spaces for faster convergence of the conjugate gradient method in the resolution of sequences of linear systems.
Gosselet, Pierre, Pebrel, Julien, Rey, Christian   +2 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On damping created by heterogeneous yielding in the numerical analysis of nonlinear reinforced concrete frame elements

, 2015
In the dynamic analysis of structural engineering systems, it is common practice to introduce damping models to reproduce experimentally observed features.
Cottereau, Régis, Jehel, Pierre
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

EU-NICE, Eurasian University Network for International Cooperation in Earthquakes [PDF]

, 2012
Despite the remarkable scientific advancements of earthquake engineering and seismology in many countries, seismic risk is still growing at a high rate in the world’s most vulnerable communities.
Braga, F., Capelli, M., Cecchini, A., Dixit, A., Dost-Safi, M., Faggella, M., Gigliotti, R., Kumar, H., Laterza, M., Limkatanyu, S., Lodi, S., Lukkunaprasit, P., Monti, G., Rahman, Z., Salvatore, W., Spacone, E., Subedi, J., Triantafillou, T., Varum, H., Xiao, Y., Yingmin, L.   +20 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Seismic vulnerability of existing buildings: non-invasive approach for dynamic behaviour assessment

GEOmedia, 2018
This paper presents a brief overview of the concept of seismic risk, with particular regard to existing civil buildings. Given that the seismic risk can be expressed as a combination involving seismic hazard and seismic vulnerability, these aspects are ...
Gianluca Acunzo, Michele Vicentino, Antonio Bottaro   +2 more
doaj  

Didactic strategies for comprehension and learning of structural concepts

, 2010
p. 926-937In previous papers we have established the convenience of formulating educational strategies at the university level for both disciplines: Civil Engineering and Architecture, which involves academic topics of mutual interest by means of ...
ABAD, Antonio, GARCIA M., Carlos, GERDINGH, Juan G., GONZALEZ C., Oscar, MORENO, Carlos   +4 more
core