Results 101 to 110 of about 2,315,081 (285)

Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes

Frontiers in Immunology
IntroductionDiabetes mellitus (DM) is recognized as one of the oldest chronic diseases and has become a significant public health issue, necessitating innovative therapeutic strategies to enhance patient outcomes.
Abbas Khan, Muhammad Ammar Zahid, Anwar Mohammad, Abdelali Agouni   +3 more
doaj   +1 more source

Prompt Engineering for Transformer-based Chemical Similarity Search Identifies Structurally Distinct Functional Analogues [PDF]

, 2023
Clayton W. Kosonocky, Aaron L. Feller, Claus O. Wilke, Andrew D. Ellington   +3 more
openalex   +1 more source

The nature of engineering change in a complex product development cycle [PDF]

, 2009
The complex dynamics of modern business mean companies are constantly exposed to rapid and radical change. The way by which a company copes with change, can act as an insight into its propensity for sustainable profitability and hence predicted longevity.
Boyle, I.M., Duffy, Alex H.B., EPSRC and Babcock Marine (Funder), Masson, Nick, Babcock Marine, Rosyth, Rowell, William   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Systematic Mapping of Circular Economy in Structural Engineering

Buildings
Facing increasing sustainability demands, the construction industry is at a turning point where the implementation of circular economy (CE) strategies plays an essential role in driving the necessary transformation aimed at reducing the environmental ...
Hanne Rangnes Seeberg, Sverre Magnus Haakonsen, Marcin Luczkowski   +2 more
doaj   +1 more source

An Improved Guide-Weight Method Without the Sensitivity Analysis

IEEE Access, 2019
This paper proposes an improved guide-weight method, in which the sensitivity analysis does not need to be calculated. Based on the Kuhn-Tucker extreme condition, the general iterative criterion of the improved guide-weight method is derived by importing
Hong-Yu Jiao, Ying Li, Lan-Yu Yang
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An engineering constraint method for continuum structural topology optimization [PDF]

, 2017
Jianfeng Zhu, Xiaokai Chen
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source