Results 51 to 60 of about 2,315,081 (285)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Contribution to probabilistic modeling of soil geo-mechanical properties for structural reliability analysis of buried pipes and foundations

open access: yesJournal of Materials and Engineering Structures, 2019
This present study synthesizes a numerical approach to optimize foundation systems design and underground pipes based on the combination of elastoplastic soil behavior and probabilistic modeling of its geo-mechanical characteristics.
Nabil KAZI TANI   +3 more
doaj  

Building Information Modelling in Structural Engineering: A Qualitative Literature Review

open access: yesCivilEng, 2021
Over the past decade, the fields of civil engineering, i.e., structural engineering, have increasingly used the building information modelling (BIM) approach in both professional practice and as the focus of research.
Vittoria Ciotta   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Parameters design for a non-linear absorber based on phase trajectory analysis

open access: yesThe Journal of Engineering, 2018
The performance of non-linear absorbers for suppression of the structure vibrations depends on the setting of the absorbers' parameters to a certain extent.
Yuan Liu, Feng Wang, Dedong Han
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Seismic evaluation of ±800 kV UHVDC disconnect switch by shake table test

open access: yesThe Journal of Engineering, 2019
Disconnect switches, the widely used electrical substation apparatuses, however, were severely damaged in several earthquakes, causing huge economic losses.
Jiayi Wen, Qiang Xie
doaj   +1 more source

Phenomenological rate-independent uniaxial hysteretic models: A mini-review

open access: yesFrontiers in Built Environment, 2022
A great variety of phenomenological models has been proposed over the years to model rate-independent hysteretic forces in structural mechanics. The classification of such models is usually based on the type of equation that needs to be solved to ...
Raffaele Capuano   +2 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

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