Results 71 to 80 of about 2,389,484 (283)
ComputationHorizontally curved steel I-beams exhibit a complicated mechanical response as they experience a combination of bending, shear, and torsion, which varies based on the geometry of the beam at hand. The behaviour of these beams is therefore quite difficult
Elvis Ababu +2 more
doaj +1 more source
Revue d'anthropologie des connaissances, 2014 Recent challenges such as sustainable development and climate change suggest engineers to focus on societal issues. However, as this case study of structural design shows, professional arrangements within the construction field constrain engineers ...
Andrew Chilvers, Sarah Bell
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Study on energy conservation and carbon emission reduction design of timber structure building
The Journal of Engineering, 2019 Replacing traditional building materials with renewable and sustainable materials such as timber can control environmental pollution such as energy consumption and carbon emission in the whole life cycle of a building, which is conducive to energy ...
Miao Yue +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Deflection characterisation of rotary systems using ground-based radar
The Journal of Engineering, 2019 In the last two decades, an increase in large rotary machines/systems has been witnessed. To ensure safe operation of these systems especially due to extreme stress caused by centrifugal forces as well as the wind or water loadings, regular structural ...
Francis X. Ochieng +6 more
doaj +1 more source
Integration of Design, Thermal, Structural, and Optical Analysis, Including Thermal Animation [PDF]
, 1993 In many industries there has recently been a concerted movement toward 'quality management' and the issue of how to accomplish work more efficiently.
Amundsen, Ruth M.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Periodic Layout Optimization of Cyclic Symmetric Structure
IEEE Access, 2019 This paper proposes a new optimization method to solve periodic layout optimization of a cyclic symmetric structure by means of the guide-weight method.
Hong-Yu Jiao, Ying Li, Lan-Yu Yang
doaj +1 more source