Results 71 to 80 of about 8,001,731 (371)
Frontiers in Built Environment, 2018 Governments and professional groups related to civil engineering write and publish standards and codes to protect the safety of critical infrastructure. In recent decades, countries have developed codes and standards for structural health monitoring (SHM)
Fernando Moreu +4 more
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Seismic evaluation of ±800 kV UHVDC disconnect switch by shake table test
The Journal of Engineering, 2019 Disconnect switches, the widely used electrical substation apparatuses, however, were severely damaged in several earthquakes, causing huge economic losses.
Jiayi Wen, Qiang Xie
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Prompt Engineering for Transformer-based Chemical Similarity Search Identifies Structurally Distinct Functional Analogues [PDF]
, 2023 Clayton W. Kosonocky +3 more
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]
, 2010 William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core +1 more source
Structural Engineering for High‐Performance Flexible and Stretchable Strain Sensors
Advanced Intelligent Systems, 2021 Structural engineering is proved to be effective in improving both measurement sensitivity and range for flexible and stretchable strain sensors. Herein, the latest advancements in structural engineering strategies are summarized for the improvement of ...
Xin Huang, Zhouping Yin, Hao Wu
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source