Results 81 to 90 of about 1,027,895 (271)

Future Automation Engineering using Structural Graph Convolutional Neural Networks [PDF]

, 2018
The digitalization of automation engineering generates large quantities of engineering data that is interlinked in knowledge graphs. Classifying and clustering subgraphs according to their functionality is useful to discover functionally equivalent engineering artifacts that exhibit different graph structures.
arxiv   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Periodic Layout Optimization of Cyclic Symmetric Structure

IEEE Access, 2019
This paper proposes a new optimization method to solve periodic layout optimization of a cyclic symmetric structure by means of the guide-weight method.
Hong-Yu Jiao, Ying Li, Lan-Yu Yang
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Multi-Temporal InSAR Structural Damage Assessment: The London Crossrail Case Study

Remote Sensing, 2018
Spaceborne multi-temporal interferometric synthetic aperture radar (MT-InSAR) is a monitoring technique capable of extracting line of sight (LOS) cumulative surface displacement measurements with millimeter accuracy.
Pietro Milillo, Giorgia Giardina, Matthew J. DeJong, Daniele Perissin, Giovanni Milillo   +4 more
doaj   +1 more source

Towards a Systems Engineering based Automotive Product Engineering Process [PDF]

arXiv, 2020
Deficit and redundancies in existing automotive product development hinder a systems engineering based development. In this paper we discuss a methodical procedure to eliminate deficits in the current product development and in turn to enable the introduction of a new systems engineering based development methodology.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Contribution to probabilistic modeling of soil geo-mechanical properties for structural reliability analysis of buried pipes and foundations

Journal of Materials and Engineering Structures, 2019
This present study synthesizes a numerical approach to optimize foundation systems design and underground pipes based on the combination of elastoplastic soil behavior and probabilistic modeling of its geo-mechanical characteristics.
Nabil KAZI TANI, Djamel NEDJAR, Tawfik TAMINE, Mabrouk HAMANE   +3 more
doaj  

Vulnerability and Robustness of Civil Infrastructure Systems to Hurricanes

Frontiers in Built Environment, 2017
Civil infrastructure systems play an important role in community resilience. Without proper functioning of the infrastructure, especially power delivery, society will not recover quickly from disruptive events, such as hurricanes.
Shuoqi Wang, Dorothy A. Reed
doaj   +1 more source

Content and structure of laboratory packages for software engineering experiments [PDF]

Information and Software Technology, 97, 64-79, 2018
Context: Experiment replications play a central role in the scientific method. Although software engineering experimentation has matured a great deal, the number of experiment replications is still relatively small. Software engineering experiments are composed of complex concepts, procedures and artefacts.
arxiv   +1 more source