Results 61 to 70 of about 1,607,586 (321)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Data-Driven Exploration of Sc-Induced mechanical enhancement in Al-Cu-Li alloys

Materials & Design
A data-driven strategy was developed to identify microalloying elements that simultaneously enhance the yield strength, elongation, and elastic modulus of Al-Cu-Li alloys. Among 71 T6-tempered compositions, Sc was identified as the most promising element
Lyu Jing, Li Yanan, Li Xiwu, Zheng Lei, Li Changlin, Xiao Wei, Wen Kai, Li Ying   +7 more
doaj   +1 more source

Applications of generative design in structural engineering [PDF]

Revista ingeniería de construcción, 2021
G. Díaz, R. F. Herrera, F. C. Muñoz-La Rivera, E. Atencio   +3 more
openaire   +1 more source

Hyaluronan hydration generates three-dimensional meso-scale structure in engineered collagen tissues [PDF]

Journal of The Royal Society Interface, 2012
Here, we show that the local incorporation of osmotically active hyaluronan into previously compressed collagen constructs results in further rapid dehydration/compression of collagen layers, channel formation and generation of new interfaces; these novel structures, at the nano–micro (i.e.
Nelomi, Anandagoda, Daniel G, Ezra, Umber, Cheema, Maryse, Bailly, Robert A, Brown   +4 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A new finite element for generalized in-plane pipe loading. Experimental and numerical comparison [PDF]

, 2010
In structural engineering, the geometry of a large number of structural details may involve the combination of straight and curved parts in order to meet requirements of functionality and/or attractive design.
Fonseca, E.M.M., Melo, F.J.M.Q. de, Oliveira, C.A.M de, Piloto, P.A.G.   +3 more
core  

Aging concrete structures: a review of mechanics and concepts [PDF]

, 2018
The safe and cost-efficient management of our built infrastructure is a challenging task considering the expected service life of at least 50 years. In spite of time-dependent changes in material properties, deterioration processes and changing demand by
Wan-Wendner, Roman
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Multimodel structural performance monitoring [PDF]

, 2015
Journal ArticleMeasurements from load tests may lead to numerical models that better reflect structural behavior. This kind of system identification is not straightforward due to important uncertainties in measurement and models.
Goulet, James-A., Kripakaran, Prakash, Smith, Ian F.C.   +2 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source