Results 101 to 110 of about 2,983,469 (361)

Sustainable structural engineering strategies for tall buildings [PDF]

open access: yesThe Structural Design of Tall and Special Buildings, 2008
AbstractSustainable structural engineering strategies for tall buildings are presented with an emphasis on stiffness‐based material‐saving design methodologies. The design methodologies are applied to the systems with diagonals such as braced tubes and more recently developed diagrid structures.
openaire   +2 more sources

Machine learning techniques for diagrid building design: Architectural-Structural correlations with feature selection and data augmentation [PDF]

open access: yes
Artificial intelligence (AI) and machine learning (ML) techniques are transforming building engineering. This work goes through the critical role of architectural parameters in influencing the structural responses of tall buildings, with a special focus ...
Entezami, Alireza   +2 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Architected Lattices with a Topological Transition

open access: yesAdvanced Engineering Materials, EarlyView., 2023
This article develops topological metamaterials showing multidirectional two‐step deformation under compression by embedding contact‐enabled topological mechanisms into lattice structures. Experiments on 3D‐printed 2D and 3D lattices and finite element simulations are conducted to demonstrate the working principle of the topological metamaterials.
Shivam Agarwal, Lihua Jin
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

open access: yesAdvanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal   +3 more
wiley   +1 more source

Automated Detection of Pre-Disaster Building Images from Google Street View [PDF]

open access: yesarXiv, 2019
After a disaster, teams of structural engineers collect vast amounts of images from damaged buildings to obtain lessons and gain knowledge from the event. Images of damaged buildings and components provide valuable evidence to understand the consequences on our structures.
arxiv  

Designer Bugs: Structural Engineering to Build a Better Mouse Model [PDF]

open access: yesCell Host & Microbe, 2007
Many animal models of bacterial diseases are hampered by differences in tissue tropism and the course of pathogenesis. In a recent issue of Cell, by rationally mutating a surface invasion protein (InlA) to have higher binding affinity for its cognate host receptor (E-cadherin), Wollert et al.
Bhaskaran Shyam S, C. Erec Stebbins
openaire   +3 more sources

The History of Wrought and Cast Iron [PDF]

open access: yes, 2004
The purpose of this thesis was to document the history, use and early application of cast and wrought iron in Structural Engineering from its beginnings in the mid eighteenth century to the early twentieth century.
Dyke, Shawn Van
core   +1 more source

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