Results 41 to 50 of about 563,295 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Potential of Self-Tempered Martensite and Bainite in Improving the Fatigue Strength of Thermomechanically Processed Steels [PDF]

MATEC Web of Conferences, 2018
In contrast to a two-stage hardening and tempering process, the definition of optimized cooling routes after hot working of low-alloy Cr steel allows the adjustments of high-strength microstructures with a sufficient degree of ductility at the same time ...
Krupp Ulrich, Solovev Mikhail, Honecker Felix, Adams Bernhard, Florian Jan-Christoph   +4 more
doaj   +1 more source

Structural parameterizations of vertex integrity

Theoretical Computer Science
The graph parameter vertex integrity measures how vulnerable a graph is to a removal of a small number of vertices. More precisely, a graph with small vertex integrity admits a small number of vertex removals to make the remaining connected components small. In this paper, we initiate a systematic study of structural parameterizations of the problem of
Tatsuya Gima, Tesshu Hanaka, Yasuaki Kobayashi, Ryota Murai, Hirotaka Ono 0001, Yota Otachi   +5 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Flexible Additively Manufactured Honeycombs Under Impact Loading: Effect of Topology and Orientation

Advances in Materials Science and Engineering
Additive manufacturing enables the fabrication of lightweight cellular lattices with tailorable mechanical behavior. This study examines the low-velocity impact response of thermoplastic polyurethane (TPU) honeycombs produced by fused filament ...
Amador Chapa, Á. U. Achury Florián, Daniel Eduardo Serrano Ruiz, J. P. Casas-Rodriguez, E. Cuan-Urquizo, A. Roman-Flores, P. D. Urbina-Coronado   +6 more
doaj   +1 more source

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase

Biomolecules, 2023
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer.
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Design and Verification of Multi-Mode Variable Camber Wing Trailing Edge

Engineering Proceedings
By changing the aerodynamic shape of the trailing edge of its wing, an aircraft can achieve lift and drag reduction during takeoff and landing and continuously achieve better aerodynamic efficiency while cruising, which plays an important role in the ...
Yifei Lu, Zhigang Wang, Qi Wu, Yu Yang, Gang Liu   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An Efficient High-Frequency Design Methodology for APU Inlet Mufflers Based on Axial Segmentation and Optimal Frequency Selection

Aerospace
The International Civil Aviation Organization (ICAO) sets strict limits for aircraft ramp noise, a key source of which is Auxiliary Power Unit (APU) inlet noise.
Dongwen Xue, Qun Yan, Yong Zheng, Jiafeng Yang, Yonghui Chen   +4 more
doaj   +1 more source