Results 51 to 60 of about 563,295 (265)

Clustering of frequency spectrums from different bearing fault using principle component analysis

MATEC Web of Conferences, 2017
In studies associated with the defect in rolling element bearing, signal clustering are one of the popular approach taken in attempt to identify the type of defect.
Yusof M.F.M., Nizwan C.K.E., Ong S.A., Ridzuan M.Q.M.   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Design and Testing of a Device to Investigate Dynamic Performance of Aero-Engine Rotor–Stator Rubbing Dynamics

Eng
To analyze the wear performance induced by rotor–stator rubbing in an aero-engine sealing structure under authentic operating conditions, a transonic rotor system with double bearing is constructed. This system incorporates the disk, shaft, blades, joint
Qinqin Mu, Qun Yan, Peng Sun, Yonghui Chen, Jiaqi Chang, Shiyu Huo   +5 more
doaj   +1 more source

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Nature Communications, 2017
Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
Melike Çağlayan, Julie K. Horton, Da-Peng Dai, Donna F. Stefanick, Samuel H. Wilson   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Nature Communications, 2018
DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic
Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek   +7 more
doaj   +1 more source

INTEGRATED STRUCTURAL SIZING OPTIMIZATION [PDF]

Engineering Optimization, 1987
A formulation for structural sizing optimization is presented. The method includes the displacements as state variables and thus integrates the analysis and design process into one combined step. The equilibrium equations are then used as equality constraints in an Augmented Lagrangian formulation. The method currently handles displacement constraints.
Alfredo Soeiro, Fernando Fagundo, Marc I. Hoit   +2 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Probabilistic Assessment of Structural Integrity

Axioms
A probability-based approach, combining deterministic and probabilistic methods, was developed for analyzing building and component failures, which are especially crucial for complex structures like nuclear power plants. This method links finite element and probabilistic software to assess structural integrity under static and dynamic loads. This study
Alzbutas, Robertas, Dundulis, Gintautas
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source