Results 61 to 70 of about 623,007 (310)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Numerical Simulation of Some Steel Structural Elements with Uncertain Initial Porosity

, 2021
The main research purpose of this work was to study the elasto-plastic responses of some fundamental steel structural elements exhibiting stochastic volumetric microvoids. The constitutive model of the steel material was consistent with the deterministic
Marcin Kamiński, Michał Strąkowski
core   +1 more source

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Nature Communications, 2017
Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
Melike Çağlayan, Julie K. Horton, Da-Peng Dai, Donna F. Stefanick, Samuel H. Wilson   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Design and Testing of a Device to Investigate Dynamic Performance of Aero-Engine Rotor–Stator Rubbing Dynamics

Eng
To analyze the wear performance induced by rotor–stator rubbing in an aero-engine sealing structure under authentic operating conditions, a transonic rotor system with double bearing is constructed. This system incorporates the disk, shaft, blades, joint
Qinqin Mu, Qun Yan, Peng Sun, Yonghui Chen, Jiaqi Chang, Shiyu Huo   +5 more
doaj   +1 more source

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Nature Communications, 2018
DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic
Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek   +7 more
doaj   +1 more source

Probabilistic Assessment of Structural Integrity

Axioms
A probability-based approach, combining deterministic and probabilistic methods, was developed for analyzing building and component failures, which are especially crucial for complex structures like nuclear power plants. This method links finite element and probabilistic software to assess structural integrity under static and dynamic loads. This study
Alzbutas, Robertas, Dundulis, Gintautas
openaire   +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Experimental Study on the Thermal Stability of Aluminum Alloy 7075-T651 Structural Parts after Rolling Correction

, 2023
The rolling correction process can eliminate machining distortions of aluminum alloy 7075-T651 structural parts. The thermal stability of the corrected structural parts under the action of temperature loading, especially the macroscopic shape stability ...
Xiaodong Jia, Zhonglei Wang, Qingqiang Chen, Jie Sun, Meizhen Qin, Laixiao Lu, Shourong Jiao   +6 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source