Results 251 to 260 of about 690,575 (314)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI. [PDF]

NPJ Precis Oncol
Alvarez-Jimenez C, Antunes JT, DeSilvio T, Wei Z, Ismail M, Willis JE, Steinhagen E, Purysko A, Liska D, Krishnamurthi S, Crittenden M, Gough M, Young K, Madabhushi A, Romero E, Tiwari P, Viswanath SE.   +16 more
europepmc   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

An integrated approach to uncertainty and global sensitivity analysis in penstock structural modeling. [PDF]

Heliyon
Haddouch M, Hajjout I, Boudi EM.
europepmc   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Structural modeling reveals viral proteins that manipulate host immune signaling

Tal N, Hadari R, Chang RB, Osterman I, Jacobson R, Yirmiya E, Bechon N, Hochhauser D, Rivera ML, Madhala B, Garb J, Wein T, Kranzusch P, Amitai G, Sorek R.   +14 more
europepmc   +1 more source

The molecular architecture of the desmosomal outer dense plaque by integrative structural modeling. [PDF]

Protein Sci
Pasani S, Menon KS, Viswanath S.
europepmc   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Editorial: Data-driven vaccine design for microbial-associated diseases

Frontiers in Immunology
Gurudeeban Selvaraj, Satyavani Kaliamurthi, Satyavani Kaliamurthi, Dongqing Wei, Dongqing Wei, Dongqing Wei   +5 more
doaj   +1 more source

A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modeling potential. [PDF]

Nucleic Acids Res
Sarnowski CP, Knörlein A, de Vries T, Götze M, Beusch I, Aebersold R, Allain FH, Hall J, Leitner A.   +8 more
europepmc   +1 more source