Results 131 to 140 of about 3,980,363 (270)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Mechanics of Deformation and Structure Formation in Composites Based on Metal-Polymer Dispersed Systems

Механика машин, механизмов и материалов, 2008
The deformation processes of metal-polymer copper-polytetrafluoroethylene powder system have been investigated by computer methods. The structural models have been developed, the values of displacements and stresses have been defined.
T.V. Ryabchenko, V.A. Kovtun, Yu.M. Pleskachevsky   +2 more
doaj  

Marginal structural models with latent class growth analysis of treatment trajectories: Statins for primary prevention among older adults. [PDF]

Stat Methods Med Res, 2023
Diop A, Sirois C, Guertin JR, Schnitzer ME, Candas B, Cossette B, Poirier P, Brophy J, Mésidor M, Blais C, Hamel D, Tadrous M, Lix L, Talbot D.   +13 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Building Structural Models of a Whole Mycoplasma Cell. [PDF]

J Mol Biol, 2022
Maritan M, Autin L, Karr J, Covert MW, Olson AJ, Goodsell DS.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Topological Constraints in Eukaryotic Genomes and How They Can Be Exploited to Improve Spatial Models of Chromosomes

Frontiers in Molecular Biosciences, 2019
Angelo Rosa, Marco Di Stefano, Cristian Micheletti   +2 more
doaj   +1 more source

STRUCTURAL MODELS OF TERM FORMATION IN UKRAINIAN IT DISCOURSE: TRANSFORMATIONS AND TRENDS

Вісник Київського національного лінгвістичного університету. Серія: Філологія
The article presents a comprehensive analysis of the structural models used in the formation of terms in modern Ukrainian IT discourse and traces their transformation under the influence of the English language and current trends in information ...
O. B. Lysychenko, Kh. B. Melko
doaj   +1 more source

Causal inference in survival analysis using longitudinal observational data: Sequential trials and marginal structural models. [PDF]

Stat Med, 2023
Keogh RH, Gran JM, Seaman SR, Davies G, Vansteelandt S.   +4 more
europepmc   +1 more source