Results 141 to 150 of about 1,433,776 (263)

Efficient global accuracy estimation for protein complex structural models using multi-view representation learning. [PDF]

Cell Rep Methods
Liu D, Zhao X, Zhang T, Xie L, Ye E, Liang F, Wang H, Zhang G.   +7 more
europepmc   +1 more source

Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. [PDF]

ACS Chem Neurosci, 2022
Berselli A, Alberini G, Benfenati F, Maragliano L.   +3 more
europepmc   +1 more source

Topological Constraints in Eukaryotic Genomes and How They Can Be Exploited to Improve Spatial Models of Chromosomes

Frontiers in Molecular Biosciences, 2019
Angelo Rosa, Marco Di Stefano, Cristian Micheletti   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

ModelArchive: A Deposition Database for Computational Macromolecular Structural Models. [PDF]

J Mol Biol
Tauriello G, Waterhouse AM, Haas J, Behringer D, Bienert S, Garello T, Schwede T.   +6 more
europepmc   +1 more source

The missing link: covalent linkages in structural models. [PDF]

Acta Crystallogr D Struct Biol, 2021
Nicholls RA, Wojdyr M, Joosten RP, Catapano L, Long F, Fischer M, Emsley P, Murshudov GN.   +7 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Marginal structural models for quantifying the causal effects of exposure to ambient air pollution on progression of CT emphysema in the MESA lung and MESA air studies. [PDF]

Am J Epidemiol
Malinsky D, Wang M, Heise R, Pistenmaa CL, Hoffman EA, Sheppard L, Szpiro AA, Laine A, Angelini ED, Smith BM, Kaufman JD, Barr RG.   +11 more
europepmc   +1 more source

Use of structural models to elucidate the occurrence of falls among older adults according to abdominal obesity: a cross-sectional study. [PDF]

Sao Paulo Med J, 2023
Monteiro ELF, Ikegami ÉM, Oliveira NGN, Reis ECD, Virtuoso Júnior JS.   +4 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source