Results 131 to 140 of about 1,353,067 (263)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Structural models for spreading and scaling digital health initiatives: A scoping review protocol. [PDF]

PLoS One
Laur C, Lee K, Milat A, Petrie S, Ladak Z, Lui V, Hall A, Nathan N, Medeiros P, Ivers N, Bhattacharyya O.   +10 more
europepmc   +1 more source

Estimation of marginal structural models under irregular visits and unmeasured confounder: calibrated inverse probability weights. [PDF]

BMC Med Res Methodol, 2023
Kalia S, Saarela O, Escobar M, Moineddin R, Greiver M.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Revealing deep evolutionary relationships between RNA viruses using predicted structural models of viral RNA polymerases. [PDF]

Mol Biol Evol
Mönttinen HAM, Ravantti JJ, Mayne R, Simmonds P, Poranen MM.   +4 more
europepmc   +1 more source

Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. [PDF]

ACS Chem Neurosci, 2022
Berselli A, Alberini G, Benfenati F, Maragliano L.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Efficient global accuracy estimation for protein complex structural models using multi-view representation learning. [PDF]

Cell Rep Methods
Liu D, Zhao X, Zhang T, Xie L, Ye E, Liang F, Wang H, Zhang G.   +7 more
europepmc   +1 more source

The missing link: covalent linkages in structural models. [PDF]

Acta Crystallogr D Struct Biol, 2021
Nicholls RA, Wojdyr M, Joosten RP, Catapano L, Long F, Fischer M, Emsley P, Murshudov GN.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source