Results 131 to 140 of about 1,433,776 (263)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Structural models for spreading and scaling digital health initiatives: A scoping review protocol. [PDF]

PLoS One
Laur C, Lee K, Milat A, Petrie S, Ladak Z, Lui V, Hall A, Nathan N, Medeiros P, Ivers N, Bhattacharyya O.   +10 more
europepmc   +1 more source

Causal inference in survival analysis using longitudinal observational data: Sequential trials and marginal structural models. [PDF]

Stat Med, 2023
Keogh RH, Gran JM, Seaman SR, Davies G, Vansteelandt S.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Heat-related illness and chronic obstructive pulmonary disease: causal inference using marginal structural models. [PDF]

BMC Public Health
Jin T, Kim S, Lee S, Kim S, Oh JK, Park B, Kim B.   +6 more
europepmc   +1 more source

Mechanistic Analysis of the VirA Sensor Kinase in Agrobacterium tumefaciens Using Structural Models. [PDF]

Front Microbiol, 2022
Swackhammer A, Provencher EAP, Donkor AK, Garofalo J, Dowling S, Garchitorena K, Phyo A, Ramírez Veliz N, Karen M, Kwon A, Diep R, Norris M, Safo MK, Pierce BD.   +13 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Revealing deep evolutionary relationships between RNA viruses using predicted structural models of viral RNA polymerases. [PDF]

Mol Biol Evol
Mönttinen HAM, Ravantti JJ, Mayne R, Simmonds P, Poranen MM.   +4 more
europepmc   +1 more source

Estimation of marginal structural models under irregular visits and unmeasured confounder: calibrated inverse probability weights. [PDF]

BMC Med Res Methodol, 2023
Kalia S, Saarela O, Escobar M, Moineddin R, Greiver M.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source