Results 41 to 50 of about 1,128,803 (283)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Machine tool FEM model correction assisted by dynamic evolution sequence

Scientific Reports
In the simulation analysis of large-scale industrial instruments such as machine tools, in order to ensure simulation accuracy, model parameter correction is necessary. This research presents a machine tool model correction method assisted by the dynamic
Weihao Lin, Peng Zhong, Xindi Wei, Li Zhu, Xuanlong Wu   +4 more
doaj   +1 more source

Dynamic Response Prediction Model for Jack-Up Platform Pile Legs Based on Random Forest Algorithm

Journal of Marine Science and Engineering
Jack-up offshore platforms are widely used in many fields, and it is of great importance to quickly and accurately predict the dynamic response of platform pile leg structures in real time.
Xiaohui Cui, Hui Liu, Xiang Lin, Jiahe Zou, Yu Wang, Bo Zhou   +5 more
doaj   +1 more source

Design of hierarchical microstructures with isotropic elastic stiffness

Materials & Design, 2023
Elastic stiffness is one of the most fundamental properties of materials. Design of the microstructures with isotropic stiffness has been an attractive area in the field of metamaterials for over three decades.
Xue Yu, Fengwen Wang, Zhen Luo, Zhan Kang, Yiqiang Wang   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Hollow Shell‐Lattice Soft Robot in Flexible Pipelines with Flowing Fluids

Advanced Science
Pipeline‐crawling soft robots are increasingly preferable for effective inspection and maintenance of flexible pipes. However, most existing robots occupy the pipe cross‐sections, disrupting the normal operation of the working systems.
Di Guo, Yiqiang Wang, Zhan Kang
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Self-supporting structure design in additive manufacturing through explicit topology optimization

, 2017
One of the challenging issues in additive manufacturing (AM) oriented topology optimization is how to design structures that are self-supportive in a manufacture process without introducing additional supporting materials. In the present contribution, it
Du, Zongliang, Guo, Xu, Liu, Chang, Liu, Ying, Zhang, Weisheng, Zhou, Jianhua   +5 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source