Results 71 to 80 of about 1,128,803 (283)

A Bayesian approach to constrained single- and multi-objective optimization [PDF]

, 2016
This article addresses the problem of derivative-free (single- or multi-objective) optimization subject to multiple inequality constraints. Both the objective and constraint functions are assumed to be smooth, non-linear and expensive to evaluate.
A Bayesian, Emmanuel Vazquez, Emmanuel Vazquez, Hal Id Hal, Julien Bect, Julien Bect, Paul Feliot, Paul Feliot   +7 more
core   +5 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Dynamic Characteristics of the Water Entry of a Lifeboat

Journal of Marine Science and Engineering
The International Convention for the Safety of Life at Sea (SOLAS) stipulates that all ships must be equipped with lifesaving devices. The freefall lifeboat has the advantages of simple operation, fast release speed, and good safety performance, so it is
Wenxin Yi, Hui Liu, Jiahe Zou, Conghong Lu, Wenqing Luo, Bo Zhou   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Numerical Study of Vortex-Induced Vibration Characteristics of a Long Flexible Marine Riser

Journal of Marine Science and Engineering
In ocean engineering, interactions between ocean currents and risers lead to regular vortex shedding on both sides of the riser, causing structural deformation.
Jiahe Zou, Bo Zhou, Wenxin Yi, Conghong Lu, Hui Liu, Wenqing Luo   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Passive Time Reversal Method with a Metamodel for Underwater Source Localization

Journal of Marine Science and Engineering
A passive time reversal method with a metamodel (PTR-MM) is proposed to improve underwater source localization under ocean conditions. PTR-MM eliminates model mismatch errors by replacing the conventional sound propagation model with a Kriging metamodel.
Jiang Liu, Sheng Li
doaj   +1 more source

Continuous Optimization of Adaptive Quadtree Structures

, 2018
We present a novel continuous optimization method to the discrete problem of quadtree optimization. The optimization aims at achieving a quadtree structure with the highest mechanical stiffness, where the edges in the quadtree are interpreted as ...
Wu, Jun
core   +1 more source

Idempotent Structures in Optimization [PDF]

Journal of Mathematical Sciences, 2001
This survey may be considered as an abridged version of the monographs [\textit{V. N. Kolokoltsov} and \textit{V. P. Maslov}, ``Idempotent analysis and its applications to the optimal control'' (in Russian) (1994; Zbl 0857.49022); ``Idempotent analysis and its applications'' (English translation) (1998; Zbl 0941.93001)] updated with some of the more ...
openaire   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source