Results 101 to 110 of about 201,361 (344)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Ontic Structural Realism and Natural Necessity [PDF]
, 2015 J. Ladyman (1998-2009), Ladyman and Ross (2007) refine J. Worral's (1998) structural realism (SR), by developing an ontic structural realism (OSR) which they argue is a consistently naturalistic means of characterizing the ontology of fundamental physics.
Kallfelz, William
core
Localism vs. Individualism for the Scientific Realism Debate [PDF]
, 2019 Localism is the view that the unit of evaluation in the scientific realism debate is a single scientific discipline, sub-discipline, or claim, whereas individualism is the view that the unit of evaluation is a single scientific theory.
Block Ned +10 more
core +4 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Structural Realism and the Interpretation of Mathematical Structure
, 2022 Noah Stemeroff
openalex +1 more source
The Structural Metaphysics of Quantum Theory and General Relativity [PDF]
, 2018 The paper compares ontic structural realism in quantum physics with ontic structural realism about space-time. We contend that both quantum theory and general relativity theory support a common, contentful metaphysics of ontic structural realism.
Esfeld, Michael, Lam, Vincent
core
Why critical realism fails to justify critical social research [PDF]
, 2009 Many social scientists have argued that research should be designed to perform a ‘critical’ function, in the sense of challenging the socio-political status quo.
Hammersley, Martyn
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Critical Realism and Empirical Research Methods in Education [PDF]
, 2005 In the light of recent writings of Richard Pring, and in relation to the application of empirical research methods in education, this paper offers a corrective to a neo-realist viewpoint and develops a critical realist perspective.
Scott, David
core +3 more sources
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source