Results 111 to 120 of about 202,206 (297)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Tone as Ontology: A Structural Account of Being Grounded in Generative Invariants
PhilosophiesThis paper develops Tone as Ontology, a structural account of being grounded in the invariants of generative systems. We articulate the ontological significance of tone, distinguishing this foundational work from a companion paper that explores its ...
Jonah Y. C. Hsu
doaj +1 more source
From Classic Realism to Iranian Realism a Frame Work for Explaining Iranian Foreign Relations with Great Powers (1501-1979) [PDF]
Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2016 Theorizing History of Iranian foreign relations can help researchers to understand the weaknesses of Iranian foreign policy toward great powers during the last five centuries.
Seydreza Mousavinia
doaj
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Empiricism, Structuralism and Scientific Change
Principia: An International Journal of Epistemology, 2008 In the last decades there was a structural turn in the classic debate between scientific realists and antirealists with empiricist orientation. Two main arguments support the realist conception: the ‘No Miracle Argument’ and the thesis of continuity. The
Susana Lucero
doaj
Eliminative Ontic Structural Realism and the Metaphysical Underdetermination Argument: A Critique
Studia Philosophiae ChristianaeIn this paper I address the problem of justifying Steven French’s eliminative ontic structural realism by the metaphysical underdetermination argument.
Damian Luty
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Algumas notas sobre realismo e ultrarealismo em Sartre
DoisPontos, 2006 This paper intends to research the possibility of thinking the several elements of Sartre's works according to one axe named "realism". It is important to explain what "realism" means here. Not intending find out a definition of "realism". Here "realism"
Alexandre de Oliveira Torres Carrasco
doaj
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source