Results 101 to 110 of about 3,439,845 (290)

Rationalist and Sentimentalist Realism: A Re-examination of the Types of Metaethical Realism and Their Implications [PDF]

open access: yesInternational Multidisciplinary Journal of Pure Life
SUBJECT & OBJECTIVES: Ontological inquiry constitutes one of the central concerns of metaethics. Within this field, theories are commonly divided into two main categories: realist and non-realist.
Ali Ahmadi Amin, Mohammad Mahdi Monadi
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Empiricism, Structuralism and Scientific Change

open access: yesPrincipia: An International Journal of Epistemology, 2008
In the last decades there was a structural turn in the classic debate between scientific realists and antirealists with empiricist orientation. Two main arguments support the realist conception: the ‘No Miracle Argument’ and the thesis of continuity. The
Susana Lucero
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Against digital ontology [PDF]

open access: yes, 2008
The paper argues that digital ontology (the ultimate nature of reality is digital, and the universe is a computational system equivalent to a Turing Machine) should be carefully distinguished from informational ontology (the ultimate nature of reality is
Floridi, Luciano, Floridi, L.
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Games and Realism [PDF]

open access: yes, 2022
Source at https://eolt.org/articles/games-and-realism.This entry offers an overview over applications of the the concept of realism in game studies. After a general description of the term, I move on to an aesthetic notion of realism before I direct ...
Pötzsch, Holger
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

From National Security to International Security Copenhagen School in Crossways of Structural Realism, English School and Social Constructivism

open access: yesCzech Journal of International Relations, 2004
The works Writingsof Buzan, Waever and their colleagues from COPRI represent the turning point in security analysis and in conceptualiszation of security in the first half of the 1990's.
Šárka Waisová
doaj  

REFINING STRUCTURAL REALISM: RESTORING PARSIMONY TO THE LOGIC OF AGGRESSION

open access: yesKAÜ-İİBF Dergisi
Structural Realism has long struggled with two critical explanatory deficits: the puzzle of "unnecessary wars" waged by Great Powers that seemingly contradict rational security calculations, and the theory’s inability to systematically account for ...
Celil Yiğit
doaj   +1 more source

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