Results 71 to 80 of about 3,799,195 (372)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Recent Advances in Text-to-Image Synthesis: Approaches, Datasets and Future Research Prospects
IEEE Access, 2023 Text-to-image synthesis is a fascinating area of research that aims to generate images based on textual descriptions. The main goal of this field is to generate images that match the given textual description in terms of both semantic consistency and ...
Yong Xuan Tan +5 more
doaj +1 more source
Generalism and the Metaphysics of Ontic Structural Realism [PDF]
, 2017 Ontic structural realism (OSR) claims that all there is to the world is structure. But how can this slogan be turned into a worked-out metaphysics? Here I consider one potential answer: a metaphysical framework known as generalism (Dasgupta, 2009, 2016).
Glick, David
core +1 more source
The structure of causal sets [PDF]
, 2011 More often than not, recently popular structuralist interpretations of physical theories leave the central concept of a structure insufficiently precisified.
B. Roberts +28 more
core +5 more sources
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
, 2013 This paper proposes to carve out a new position in the scientific realism/antirealism debate and argue that it captures some of the most important realist and some of the most important antirealist considerations.
Nanay, Bence
core +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
A possible Answer to Newman’s Objection from the perspective of informational structural realism [PDF]
, 2015 This paper aims to reconstruct a possible answer to the classical Newman’s objection which has been used countless times to argue against structural realism.
Marin, Lavinia
core +1 more source
The Realistic Angel: Pictorial Realism as Hypothetical Verity [PDF]
, 2015 My main objective in this paper is to formulate a view of pictorial realism I call ‘hypothetical verity’. It owes much to John Kulvicki but diverges from his view in an important respect: rather than thinking that realistic pictures
Buckman, Christopher
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source