Results 51 to 60 of about 1,367,188 (309)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Wind turbine condition monitoring dataset of Fraunhofer LBF

Scientific Data
Fraunhofer wind turbine dataset contains monitoring data from a 750 W wind turbine, including accelerometers and tachometer, to capture structural response, bearing vibrations and rotational velocity.
Atabak Mostafavi, Andreas Friedmann
doaj   +1 more source

Analysis of the Anisotropic Cyclic Material Behavior of EN AW-1050A H24 Derived from Strain-Controlled Testing Using a Clip-On Extensometer and an Optical System

Crystals
Due to its good conductive properties, unalloyed (pure) aluminum, such as EN AW-1050A H24, finds new fields of application in electromobility. To optimize components, the cyclic material behavior must be understood and described precisely as a foundation
Tim Korschinsky, Benjamin Möller, Marvin Kiel, Matthias Hecht   +3 more
doaj   +1 more source

Uncertainty in Crack width Estimates According to Fib Model Code 2010

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017
The contribution is focused on quantifying model uncertainty of crack width estimates for reinforced concrete beams. Predictions obtained by the model provided by the fib Model Code 2010 are compared with results of tests of beams having different ...
Mlčoch Jan, Marková Jana, Sýkora Miroslav   +2 more
doaj   +1 more source

Potential contribution of high strength, high modulus aramid fibers to the commercial feasibility of lighter than air craft [PDF]

, 1975
Kevlar aramid fiber, fabric, rope and cable performance are reviewed along with the economics relevant to the material, structural, and reliability aspects of lighter than air ...
Sturgeon, D. L. G., Venkatachalam, T. K.
core   +1 more source

Reliability analysis of structural ceramic components using a three-parameter Weibull distribution [PDF]

, 1992
Described here are nonlinear regression estimators for the three-Weibull distribution. Issues relating to the bias and invariance associated with these estimators are examined numerically using Monte Carlo simulation methods.
Duffy, Stephen F., Powers, Lynn M., Starlinger, Alois   +2 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Uncertainty in Shear Resistance of Reinforced Concrete Beams With Stirrups – Comparison of EN 1992-1-1 and fib Mc 2010 Approaches

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2014
The submitted contribution is focused on the model uncertainty related to shear resistance of reinforced concrete beams with stirrups. Using available test results, effects of basic variables on the model uncertainty are analysed. Considering the section-
Krejsa Jan, Holicky Milan, Sykora Miroslav   +2 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source