Results 51 to 60 of about 4,850,254 (305)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Uncertainty in Crack width Estimates According to Fib Model Code 2010
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017 The contribution is focused on quantifying model uncertainty of crack width estimates for reinforced concrete beams. Predictions obtained by the model provided by the fib Model Code 2010 are compared with results of tests of beams having different ...
Mlčoch Jan +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Reliability of the Structured Interview for Schizotypy-Revised [PDF]
Schizophrenia Bulletin, 2000 We investigated the reliability of the Structured Interview for Schizotypy-Revised (SIS-R). The original interview (SIS) was developed by Kendler. We revised the SIS, primarily by standardizing the rating procedures. Operational definitions and explicit criteria for rating were given.
Vollema, MG, Ormel, Johan
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2014 The submitted contribution is focused on the model uncertainty related to shear resistance of reinforced concrete beams with stirrups. Using available test results, effects of basic variables on the model uncertainty are analysed. Considering the section-
Krejsa Jan +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Influence of Graphite Degenerations on Mechanical Properties of Ductile Iron
Engineering ProceedingsDuctile iron—also known as spheroidal graphite iron (SGI)—is a versatile material that exhibits a wide range of applications. In addition to the matrix structure itself, graphite morphology and material defects, such as graphite degenerations, also have ...
Tim Steingräber, Jan Niewiadomski
doaj +1 more source
Reliability Assessment of Quick Closing Valves in Hydroeletric Power Plant
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2016 The assessment of existing components of power producing facilities is based on probabilistic methods of the theory of reliability provided in Eurocodes and ISO standards.
Marková Jana, Jung Karel
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Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source