Results 61 to 70 of about 363,848 (266)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Estimating Design Resistance of Wrought Balcony Girders

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017
The contribution is focused on reliability of balcony girders of a Czech national heritage monument. As preliminary reliability assessment suggests insufficient resistance, a series of nondestructive tests supplemented by a single tensile test are ...
Jung Karel, Marková Jana, Sýkora Miroslav   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Uncertainty in Loading and Control of an Active Column Critical to Buckling

Shock and Vibration, 2012
Buckling of load-carrying column structures is an important design constraint in light-weight structures as it may result in the collapse of an entire structure.
G.C. Enss, R. Platz, H. Hanselka
doaj   +1 more source

Structural Reliability Analysis by Using Non-Probabilistic Multi-Cluster Ellipsoidal Model. [PDF]

Entropy (Basel), 2022
Li K, Liu H.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reliability and Risk Acceptance Criteria for Civil Engineering Structures

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2016
The specification of risk and reliability acceptance criteria is a key issue of reliability verifications of new and existing structures. Current target reliability levels in standards appear to have considerable scatter.
Diamantidis Dimitris, Holický Milan, Sýkora Miroslav   +2 more
doaj   +1 more source

Approach for the structural reliability analysis by the modified sensitivity model based on response surface function - Kriging model. [PDF]

Heliyon, 2022
Zhu L, Qiu J, Chen M, Jia M.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Various Response Functions in Lattice Domes Reliability Via Analytical Integration and Finite Element Method

International Journal of Applied Mechanics and Engineering, 2018
The main aim of this work is to verify an influence of the response function type in direct symbolic derivation of the probabilistic moments and coefficients of the structural state variables of axisymmetric spherical steel dome structures.
B. Pokusiński, M. Kamiński
doaj   +1 more source