Results 61 to 70 of about 4,850,254 (305)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A clustering structure for reliable multicasting
Proceedings Eight International Conference on Computer Communications and Networks (Cat. No.99EX370), 2003 In reliable multicast, the multicast packets must be acknowledged. We propose a clustering structure which can be used by most of the existing reliable multicast protocols for collecting acknowledgements and for making local retransmissions. Given a network N and a multicast routing tree (or a set of trees) T, we consider a subgraph G of N induced by ...
Carr-Motyckova, Lenka, Jennings, Esther
openaire +4 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Empirical bayes estimates of development reliability for one shot devices [PDF]
, 2009 This article describes a method for estimating the reliability of a system under development that is an evolution of previous designs. We present an approach to making effective use of heritage data from similar operational systems to estimate ...
Quigley, J.L. +2 more
core +3 more sources
Structural reliability of existing city bridges
, 2015 Full probabilistic reliability analysis may be valuable for assessing existing structures. Measures for increasing the safety level are quite costly for existing structures and may be unnecessary when such a decision is grounded on a conservative ...
Hellebrandt, L. +3 more
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Reliability based structural design
, 2014 According to ISO 2394, structures shall be designed, constructed and maintained in such a way that they are suited for their use during the design working life in an economic way. To fulfil this requirement one needs insight into the risk and reliability
Vrouwenvelder, A.C.W.M.
core
Some optimal designs for grouped data in reliability demonstration tests
, 2011 The paper considers optimal demonstration testdesigns with grouped inspection data from logistic, log-logistic, normal/Gaussian and log-normal distributions, along with the test statistics of the mean life and reliability for ...
Wei, Duan; Bau, Jinn-jomp
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source