Results 111 to 120 of about 7,449,096 (281)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of video data from an unmanned aerial vehicle based on a structural similarity index
Компьютерная оптикаThe article proposes a metric for the analysis of video data recorded by an unmanned aerial vehicle that uses a structural similarity index for evaluation. The metric consists in comparing frames in terms of brightness, contrast and pixel structure and a
P.A. Lyakhov, A.R. Orazaev
doaj +1 more source
Similarity Continua and Criteria in Memetic Theory and Analysis [PDF]
, 2014 The aim of this article is to schematize and quantify certain of the similarity relationships which are relevant to the application of memetics to music, in order to sketch a methodology by which evolutionarily significant resemblances (particularly in ...
Jan, Steven
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On a Structural Similarity Index Approach for Floating-Point Data
IEEE Transactions on Visualization and Computer GraphicsData visualization is typically a critical component of post-processing analysis workflows for floating-point output data from large simulation codes, such as global climate models. For example, images are often created from the raw data as a means for evaluation against a reference dataset or image.
Allison H. Baker +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Index structures for similarity search in multimedia databases.
, 2006 published
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Geophysical Research LettersAccurately characterizing grid‐level vegetation dynamics in urban agglomerations remains challenging due to high spatial heterogeneity and complex temporal responses to urbanization.
Z. Q. Xie, J. C. Xie, Y. Du, N. Wang
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source