Results 181 to 190 of about 864,768 (299)

PSVRP: a pig structural variant reference panel for complex trait genomics and precision breeding. [PDF]

BMC Genomics
Li X, Quan Y, Li D, Wang Y, Yuan T, Cao M, Wang J, Ding R, Wang S, Shi X, Zhang J, Jiang Y, Derks MFL, Liu W, Liu Q, Yu T.   +15 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The editable landscape of the yeast genome reveals hotspots of structural variant formation. [PDF]

Sci Adv
Li S, Vonesch SC, Roy KR, Tu CS, Steudle F, Nguyen M, Jann C, Steinmetz LM.   +7 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Phased-assembly-driven pangenome graphs for structural variant genotyping and complex trait mapping in dairy cattle. [PDF]

Nat Commun
Yang L, Gao Y, Kuhn KL, Bhowmik N, Li W, Zanton G, Fang L, Cole JB, Li C, Baldwin Vi RL, Van Tassell CP, Rosen BD, Ma L, Smith TPL, Liu GE.   +14 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

ConsensuSV-ONT - A modern method for accurate structural variant calling. [PDF]

Sci Rep
Pietryga A, Chiliński M, Gadakh S, Plewczynski D.   +3 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Pangenome-based association testing between a structural variant located upstream of the KIT gene and head depigmentation across a diverse panel of cattle breeds. [PDF]

Genet Sel Evol
Sorin V, Sanchez MP, Drouilhet L, Tosser-Klopp G, Naji MM, Boichard D, Pausch H, Boussaha M, Leonard AS.   +8 more
europepmc   +1 more source