Results 191 to 200 of about 864,768 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Structural variant landscape provides insights into genome organisation and domestication in European seabass. [PDF]

BMC Biol
Jiao Z, Mukiibi R, Gundappa MK, Babbucci M, Prendergast JGD, Robledo D, Bargelloni L, Macqueen DJ.   +7 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Familial cerebral cavernous malformations caused by a novel germline structural variant in the KRIT1 gene. [PDF]

Neurogenetics
Pilz RA, Begemann M, Pfister S, Boonsawat P, Rauch A, Kurth I, Felbor U, Rath M.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Application of a French cattle pangenome, from structural variant discovery to association studies on key phenotypes. [PDF]

Genet Sel Evol
Sorin V, Naji MM, Birbes C, Grohs C, Escouflaire C, Fritz S, Eché C, Marcuzzo C, Suin A, Donnadieu C, Gaspin C, Iampietro C, Milan D, Drouilhet L, Tosser-Klopp G, Boichard D, Klopp C, Sanchez MP, Boussaha M.   +18 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

ASVBM: Structural variant benchmarking with local joint analysis for multiple callsets. [PDF]

Comput Struct Biotechnol J
Mu P, Feng X, Tong L, Huang J, Zhu C, Wang F, Quan W, Ma Y, Dong Y, Zhu X.   +9 more
europepmc   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

OctopuSV and TentacleSV: a one-stop toolkit for multi-sample, cross-platform structural variant comparison and analysis. [PDF]

Bioinformatics
Guo Q, Li Y, Wang TY, Ramakrishnan A, Yang R.   +4 more
europepmc   +1 more source