Results 191 to 200 of about 4,111,769 (301)

cuteHap: Haplotype-Aware Structural Variant Detection in Phased Long-Read Sequencing Data. [PDF]

Adv Sci (Weinh)
Cao S, Liu Y, Cui M, Gao R, Guo W, Wang G, Wang Y, Jiang T.   +7 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Longitudinal ctDNA tracking in early and recurrent breast cancer using an ultrasensitive structural variant-based assay: an extended analysis from the TRACER study. [PDF]

ESMO Open
Elliott MJ, Roh J, Bird T, Li M, Nadler MB, Amir E, Kumar V, Yu C, Alcaide M, Birkeälv S, Hafstad V, Gray E, de Bruin EC, Levin W, Siu LL, Bedard PL, Berman HK, Howarth K, Cescon DW.   +18 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Ring chromosomes uncovered by optical genome mapping: impact of telomeric-associated regions and reference genome selection on structural variant interpretation. [PDF]

Chromosome Res
Burssed B, Oliveira ARCP, Bellucco FT, Melaragno MI.   +3 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Optimizing GRIDSS for clinical use: A targeted NGS filtering strategy for germline structural variant detection. [PDF]

Eur J Hum Genet
Munté E, Rofes P, Millán-Castillo M, Solanes A, Muñoz X, Campos O, Alay A, Ajenjo-Bauza M, Navarro E, de la Morena-Barrio B, Salinas M, Vargas-Parra G, Cuesta R, Moreno-Cabrera JM, Cordero D, Pineda M, Del Valle J, Lázaro C, Feliubadaló L.   +18 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

SVNeoPP: A Workflow for Structural-Variant-Derived Neoantigen Prediction and Prioritization Using Multi-Omics Data. [PDF]

Biology (Basel)
An W, Tan X, Liu Z, Zou L, Lu M, Xie L.
europepmc   +1 more source